In vitro cytotoxicity activity of novel Schiff base ligand-lanthanide complexes

被引：132
作者：
Andiappan, Kavitha [1 ,2 ]
Sanmugam, Anandhavelu [1 ]
Deivanayagam, Easwaramoorthy [3 ]
Karuppasamy, K. [3 ]
Kim, Hyun-Seok [3 ]
Vikraman, Dhanasekaran [3 ]
机构：
[1] Vel Tech Multi Tech, Dept Chem S&H, Madras 600062, Tamil Nadu, India
[2] BS Abdur Rahman Univ, Dept Chem, Madras 600048, Tamil Nadu, India
[3] Dongguk Univ Seoul, Dept Elect & Elect Engn, Seoul 04620, South Korea
来源：
SCIENTIFIC REPORTS | 2018年 / 8卷
基金：
新加坡国家研究基金会;
关键词：
METAL-COMPLEXES; SPECTROSCOPIC CHARACTERIZATION; CRYSTAL-STRUCTURE; DNA-BINDING; BIOLOGICAL-ACTIVITY; ANTICANCER ACTIVITY; COPPER(II) COMPLEX; CU(II) COMPLEXES; TRANSITION-METAL; LANTHANUM(III);
D O I：
10.1038/s41598-018-21366-1
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A Schiff base ligand (SBL), N-2, N-3-bis (anthracen-9-ylmethylene) pyridine-2, 3-diamine, was synthesized through the condensation of 2,6-diaminopyridine and anthracene-9-carbaldehyde using a 1:2 ratio. H-1 NMR spectra confirmed the observation of non-involvement aromatic carboxylic proton in SBL. A novel series of lanthanide (i.e., praseodymium (Pr), erbium (Er), and ytterbium (Yb))-based SBL metal complexes was successfully synthesized, and their functional groups were elaborately demonstrated using UV-visible, Fourier transform infrared (FT-IR), and fluorescence spectroscopy analyses. FT-IR spectral studies revealed that SBL behaved as a bidentate ligand and it was structured with metal ions by the two azomethine nitrogens. The synthesized SBL-based metal complexes were elaborately performed for cytotoxicity activity versus Vero, human breast cancer (MCF7), and cervical (HeLa) anticancer cell lines.
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页数：12
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