A QSAR study on influenza neuraminidase inhibitors

被引：37
作者：
Verma, RP [1 ]
Hansch, C [1 ]
机构：
[1] Pomona Coll, Dept Chem, Claremont, CA 91711 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 04期
关键词：
hydrophobicity; molar refractivity; molar volume; number of valence electrons; neuraminidase; QSAR;
D O I：
10.1016/j.bmc.2005.09.016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Influenza is a major respiratory infection associated with significant morbidity in the general population and mortality in elderly and high-risk patients. It is ail RNA virus that contains two major surface glycoproteins, neuraminidase and hemagglutinin. These proteins are essential for infection. Neuraminidase has been found to be a potential target to control influenza virus. In this paper, we have developed 17 quantitative structure-activity relationships (QSAR) for different sets of compounds to understand chemical-biological interactions governing their activities toward influenza neuraminidase. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：982 / 996
页数：15
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