Efficacy of Morus nigra L. on reproduction in female Wistar rats

被引：16

作者：

de Queiroz, Graziela Tonioni ^{[1
]}

Santos, Tatianne Rosa ^{[1
]}

Macedo, Renato ^{[2
]}

Peters, Vera Maria ^{[1
,2
]}

Leite, Magda Narciso ^{[3
]}

da Silveira e Sa, Rita de Cassia ^{[4
]}

Guerra, Martha de Oliveira ^{[1
,2
]}

机构：

[1] Univ Fed Juiz de Fora, Programa Posgrad Ciencias Biol, Area Concentracao Comportamento & Biol Anim, BR-36036330 Juiz De Fora, MG, Brazil

[2] Univ Fed Juiz de Fora, Ctr Reprod Biol, BR-36036330 Juiz De Fora, MG, Brazil

[3] Univ Fed Juiz de Fora, Dept Farm & Bioquim, BR-36036330 Juiz De Fora, MG, Brazil

[4] Univ Fed Paraiba, Dept Fisiol & Patol, BR-58051900 Joao Pessoa, Paraiba, Brazil

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2012年 / 50卷 / 3-4期

关键词：

Morus nigra; Mulberry; Toxicology; Reproduction; Wistar rats; MULBERRY FRUIT; GLYCOSIDES; TOXICITY; IDENTIFICATION; ANTHOCYANINS; FLAVONOIDS; BERRIES; GLUCOSE; ALBA;

D O I：

10.1016/j.fct.2011.12.014

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Morus nigra L is a plant employed as a substitute for the conventional hormonal replacement therapy. This work analyzes the estrogenic effect of M. nigra on the reproductive system and embryonic development of Wistar rats. Female rats were orally treated with M. nigra hydroalcoholic extract (MnHE) at the dose levels of 25, 50, 75, 350 and 700 mg/kg of body weight over 15 days, and continued through mating until the 14th day of gestation. Vaginal smears were performed daily and the body weight of the females was recorded at 5 days intervals. On day 15 of gestation, the females were killed and their kidneys, liver, spleen and ovaries were removed and weighed. The number of implants, resorptions, and live and dead fetuses were evaluated. Histological sections of ovaries, measurement of the height of the uterine epithelium and vaginal smears were performed to assess the estrogenic activity. The results showed that the administration of MnHE did not significantly alter the analyzed variables. Therefore, considering the experimental model used in this study, the data obtained indicate that M. nigra did not exhibit any estrogenic activity nor did exert a toxic effect on the female reproductive system and on the embryonic development of rats. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：816 / 822

页数：7

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