A local application of an antioxidant for Cisplatin-ototoxicity

被引：0
|
作者：
Teranishi, M [1 ]
Nakashima, T [1 ]
机构：
[1] Nagoya Univ, Grad Sch Med, Dept Otorhinolaryngol, Nagoya, Aichi, Japan
来源：
RECENT ADVANCES IN OTITIS MEDIA, PROCEEDINGS | 2001年
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the effects of a locally applied antioxidant, trolox on CDDP (Cisplatin)-ototoxicity in guinea pigs. Drugs were put on round windows after opening the bulla via a post-auricular approach. The combined treatment of animals with trolox distinctly suppressed the CDDP-induced ototoxic side effects. These were: elevations of ABR thresholds at 4, 8 and 16 kHz; and substantial outer hair cell losses in the basal and second turns. Renal function was not impaired in each group. These results suggest that locally applied trolox provides a protective effect on CDDP-ototoxicity via the suppression of production of reactive oxygen species.
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页码：347 / 350
页数：4
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