Diagnostic potential for miRNAs as biomarkers for pregnancy-specific diseases

被引：94
作者：
Zhao, Zhen [1 ]
Moley, Kelle H. [2 ]
Gronowski, Ann M. [2 ,3 ]
机构：
[1] NIH, Ctr Clin, Bethesda, MD 20892 USA
[2] Washington Univ, Sch Med, Dept Obstet & Gynecol, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
来源：
CLINICAL BIOCHEMISTRY | 2013年 / 46卷 / 10-11期
关键词：
miRNA; Pregnancy; Biomarker; CIRCULATING MICRORNAS; MATERNAL CIRCULATION; HUMAN PLACENTAS; UNITED-STATES; EXPRESSION; PREECLAMPSIA; SERUM; IDENTIFICATION; PREDICTION; PROFILE;
D O I：
10.1016/j.clinbiochem.2013.01.026
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Discovery of circulating miRNAs in maternal blood has not only facilitated the understanding of their role in normal pregnancy, but also paved new avenues for biomarker discovery to detect pregnancy-associated complications, such as preeclampsia, ectopic pregnancy, gestational diabetes mellitus, fetal growth restriction, recurrent pregnancy loss, and preterm delivery. In this review, we summarize the studies to date of miRNAs in maternal circulation and placental tissue in human. This brief review does not cover all aspects of this intriguing field but focuses on some new and interesting findings of diagnostic potential for miRNAs as biomarkers for pregnancy-specific diseases. (C) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：953 / 960
页数：8
相关论文
共 46 条
[11]   Differential expression of microRNAs in the placentae of Chinese patients with severe pre-eclampsia [J].
Hu, Yali ;
Li, Pengfei ;
Hao, Sha ;
Liu, Liu ;
Zhao, Junli ;
Hou, Yayi .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2009, 47 (08) :923-929
[12]   Two common SNPs in pri-miR-125a alter the mature miRNA expression and associate with recurrent pregnancy loss in a Han-Chinese population [J].
Hu, Yi ;
Liu, Chun-Mei ;
Qi, Lu ;
He, Tian-Zhu ;
Shi-Guo, Liu ;
Hao, Chan-Juan ;
Cui, Yi ;
Zhang, Ning ;
Xia, Hong-Fei ;
Ma, Xu .
RNA BIOLOGY, 2011, 8 (05) :861-872
[13]   The increasing prevalence of diabetes in pregnancy [J].
Hunt, Kelly J. ;
Schuller, Kelly L. .
OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA, 2007, 34 (02) :173-+
[14]   Hydroxysteroid (17-β) Dehydrogenase 1 Is Dysregulated by Mir-210 and Mir-518c That Are Aberrantly Expressed in Preeclamptic Placentas A Novel Marker for Predicting Preeclampsia [J].
Ishibashi, Osamu ;
Ohkuchi, Akihide ;
Ali, Md. Moksed ;
Kurashina, Ryuhei ;
Luo, Shan-Shun ;
Ishikawa, Tomoko ;
Takizawa, Takami ;
Hirashima, Chikako ;
Takahashi, Kayo ;
Migita, Makoto ;
Ishikawa, Gen ;
Yoneyama, Koichi ;
Asakura, Hirobumi ;
Izumi, Akio ;
Matsubara, Shigeki ;
Takeshita, Toshiyuki ;
Takizawa, Toshihiro .
HYPERTENSION, 2012, 59 (02) :265-+
[15]   Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation [J].
Ishihara, N ;
Matsuo, H ;
Murakoshi, H ;
Laoag-Fernandez, JB ;
Samoto, T ;
Maruo, T .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2002, 186 (01) :158-166
[16]   Association study of microRNA polymorphisms with risk of idiopathic recurrent spontaneous abortion in Korean women [J].
Jeon, Young Joo ;
Choi, Yi Seul ;
Rah, HyungChul ;
Kim, Su Yeoun ;
Choi, Dong Hee ;
Cha, Sun Hee ;
Shin, Ji Eun ;
Shim, Sung Han ;
Lee, Woo Sik ;
Kim, Nam Keun .
GENE, 2012, 494 (02) :168-173
[17]   Placental-specific microRNA in maternal circulation - identification of appropriate pregnancy-associated microRNAs with diagnostic potential [J].
Kotlabova, Katerina ;
Doucha, Jindrich ;
Hromadnikova, Ilona .
JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2011, 89 (02) :185-191
[18]   Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR) [J].
Kroh, Evan M. ;
Parkin, Rachael K. ;
Mitchell, Patrick S. ;
Tewari, Muneesh .
METHODS, 2010, 50 (04) :298-301
[19]   Circulating angiogenic factors in the pathogenesis and prediction of preeclampsia [J].
Lam, C ;
Lim, KH ;
Karumanchi, SA .
HYPERTENSION, 2005, 46 (05) :1077-1085
[20]   Characterization of microRNA expression profiles in normal human tissues [J].
Liang, Yu ;
Ridzon, Dana ;
Wong, Linda ;
Chen, Caifu .
BMC GENOMICS, 2007, 8 (1)
12345