Four new sucrose diesters of substituted truxinic acids from Trigonostemon honbaensis with their anoctamin-1 inhibitory activity

被引：9

作者：

Ban, Ninh Khac ^{[1
,2
]}

Truong, Luu Hong ^{[3
]}

Tiep, Tran Van ^{[4
]}

Yen, Duong Thi Hai ^{[1
]}

Doan, Vu Van ^{[1
]}

Nhiem, Nguyen Xuan ^{[1
,2
]}

Seo, Yohan ^{[5
]}

Namkung, Wan ^{[5
]}

Kim, Seung Hyun ^{[5
]}

Tai, Bui Huu ^{[1
,2
]}

Kiem, Phan Van ^{[1
,2
]}

机构：

[1] Vietnam Acad Sci & Technol VAST, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi, Vietnam

[2] Grad Univ Sci & Technol, VAST, 18 Hoang Quoc Viet, Hanoi, Vietnam

[3] VAST, Southern Inst Ecol, 01 Mac Dinh Chi St, Ho Chi Minh City, Vietnam

[4] Nui Chua Natl Pk, Ninh Hai Dist, Ninh Thuan Prov, Vietnam

[5] Yonsei Univ, Yonsei Inst Pharmaceut Sci, Coll Pharm, Incheon 406840, South Korea

来源：

BIOORGANIC CHEMISTRY | 2020年 / 102卷

关键词：

Trigonostemon honbaensis; Trigohonbanoside; Truxinic acid sucrose diesters; Anoctamin-1; inhibitor; CHEMICAL-CONSTITUENTS; DERIVATIVES; LIGNAN; ESTERS;

D O I：

10.1016/j.bioorg.2020.104058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Truxinic acid sucrose diesters analogs possess interesting chemical structure by the presence of cyclobutane-ring and macrocyclic sucrose diesters moieties which are rarely found from natural sources. This paper describes the isolation and structural elucidation of four new sucrose diesters of substituted truxinic acids, trigohonbanosides A-D (1-4), from the leaves of Trigonostemon honbaensis. Their chemical structures were elucidated by HR-ESI-MS, NMR, and CD spectroscopic methods. At a concentration of 30 mu M, compounds 1-4 moderately inhibited ANO-1 activity with inhibitory percentages of 27.7 +/- 1.10%, 35.6 +/- 0.92%, 43.7 +/- 1.61%, and 40.8 +/- 1.25%, respectively.

引用

页数：6

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