wFeCl3-Catalyzed Intramolecular Michael Reaction of Styrenes for the Synthesis of Highly Substituted Indenes

被引：19

作者：

Dethe, Dattatraya H. ^{[1
]}

Murhade, Ganesh M. ^{[1
]}

Ghosh, Sourav ^{[1
]}

机构：

[1] Indian Inst Technol Kanpur, Dept Chem, Kanpur 208016, Uttar Pradesh, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 16期

关键词：

CONJUGATE ADDITION; ALPHA; BETA-UNSATURATED KETONES; STILBENE DERIVATIVES; ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; SIMPLE ALKENES; CYCLIZATION; ALDEHYDES; CATALYST; INHIBITORS;

D O I：

10.1021/acs.joc.5b01071

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An intramolecular FeCl3-catalyzed Michael addition reaction of styrene, a poor nudeophile, onto alpha,beta-unsaturated ketones was developed for the synthesis of highly substituted indene derivatives. The method was further applied to the total synthesis of the sesquiterpene natural products (+/-)-jungianol and 1-epi-jungianol.

引用

页码：8367 / 8376

页数：10

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