Sexual dimorphism in Parkinson's disease: differences in clinical manifestations, quality of life and psychosocial functioning between males and females

被引:14
作者
Farhadi, Farzaneh [1 ]
Vosoughi, Kia [1 ]
Shahidi, Gholam Ali [2 ]
Delbari, Ahmad [3 ,4 ]
Lokk, Johan [3 ,5 ]
Fereshtehnejad, Seyed-Mohammad [3 ,6 ,7 ]
机构
[1] Iran Univ Med Sci, Med Student Res Comm, Tehran, Iran
[2] Iran Univ Med Sci, Movement Disorders Clin, Dept Neurol, Fac Med, Tehran, Iran
[3] Karolinska Inst, Div Clin Geriatr, Dept Neurobiol Care Sci & Soc NVS, Novum Fifth Floor, S-14186 Stockholm, Sweden
[4] Univ Social Welf & Rehabil, Iranian Res Ctr Aging, Tehran, Iran
[5] Karolinska Univ Hosp, Dept Geriatr Med, Stockholm, Sweden
[6] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada
[7] Iran Univ Med Sci, Firoozgar Clin Res Dev Ctr, Firoozgar Hosp, Tehran, Iran
关键词
Parkinson's disease; sexual dimorphism; male; female; quality of life; psychosocial functioning; SLEEP BEHAVIOR DISORDER; GENDER-DIFFERENCES; DOPAMINE NEURONS; ALPHA-SYNUCLEIN; DEMENTIA; DISABILITY; IMPACT; STIGMA; WOMEN; RISK;
D O I
10.2147/NDT.S124984
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction: Sex-related differences in clinical manifestations and consequences of Parkinson's disease (PD) have been poorly explored. Better understanding of sexual dimorphism in neurologic diseases such as PD has been announced as a research priority. The aim of our study was to determine independent sex differences in clinical manifestations and subtypes, psychosocial functioning, quality of life (QoL) and its domains between male and female individuals with PD. Patients and methods: A comprehensive list of demographics, motor symptoms and subtypes, nonmotor features, health-related quality of life (HRQoL), psychosocial functioning and general aspects of daily life was assessed in 157 individuals (108 males and 49 females) with idiopathic PD. In order to control for potential confounding variables, we applied Orthogonal Partial Least Squares-Discriminant Analysis (OPLS-DA) to explore the strength of each feature to discriminate male and female patients with PD. Results: While no sex difference was found in the total Unified Parkinson's Disease Rating Scale (UPDRS) score and cumulative daily dose of levodopa, females had significantly more severe anxiety (mean difference = 2.2 [95% confidence interval, CI: 0.5-4.0], P= 0.011), worse nutritional status (23.8 [standard deviation, SD = 4.2] vs 25.8 [SD = 2.6], P= 0.003) and poorer QoL (28.3 [SD = 15.7] vs 17.9 [SD = 14.2], P<0.001). Based on multivariate discriminant analysis, emotional well-being, bodily discomfort, social support, mobility and communication domains of HRQoL, together with anxiety, depression and psychosocial functioning, were the strongest features with more severe/worse status in females after adjustment for potential statistical confounders. Conclusion: Our study provides a comprehensive understanding of sexual dimorphism in PD. Anxiety, depression, specific domains of HRQoL (mobility, emotional well-being, social support and bodily discomfort) and psychosocial functioning were significantly worse in female individuals with PD. Sexual dimorphism in PD highlights the features that are more likely to be affected in each sex and should be specifically targeted when managing male and female individuals with PD.
引用
收藏
页码:329 / 338
页数:10
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