Phenolic Compounds from Belamcanda chinensis Seeds

被引：9
作者：
Song, Ying-Ying [1 ,2 ,3 ]
Liu, Ying [2 ]
Yan, Yong-Ming [2 ]
Lu, Xi-Feng [2 ]
Cheng, Yong-Xian [2 ,4 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
[2] Shenzhen Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[4] Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450008, Henan, Peoples R China
来源：
MOLECULES | 2018年 / 23卷 / 03期
关键词：
Belamcanda chinensis; belamcanosides A and B; GC analysis; HMGCR; SQLE; LDLR; SORT1; SMAD3; PHOSPHORYLATION; CONSTITUENTS; ANTIOXIDANT; DERIVATIVES; METABOLISM; GLYCOSIDES; PROMOTER;
D O I：
10.3390/molecules23030580
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new sucrose derivatives, namely, belamcanosides A (1) and B (2), together with five other known compounds (3-7), were isolated from the seeds of Belamcanda chinensis (L.) DC. Their structures were identified based on spectroscopic data. Especially, the absolute configurations of fructose and glucose residues in 1 and 2 were assigned by acid hydrolysis, followed by derivatization and gas chromatography (GC) analysis. Among the known compounds, (-)-hopeaphenol (3), (+)-syringaresinol (4), and quercetin (5), were isolated from B. chinensis for the first time. In addition, biological evaluation of 1 and 2 against cholesterol synthesis and metabolism at the gene level was carried out. The results showed that compounds 1 and 2 could regulate the expression of cholesterol synthesis and metabolism-associated genes, including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), squalene epoxidase (SQLE), low density lipoprotein receptor (LDLR), and sortilin (SORT1) genes in HepG2 cells.
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页数：10
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