CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors

被引：93

作者：

Wanat, Matthew J. ^{[1
,2
]}

Bonci, Antonello ^{[3
,4
,5
]}

Phillips, Paul E. M. ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA

[2] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA

[3] NIDA, Intramural Res Program, Baltimore, MD USA

[4] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[5] Johns Hopkins Sch Med, Solomon H Snyder Neurosci Inst, Baltimore, MD USA

来源：

NATURE NEUROSCIENCE | 2013年 / 16卷 / 04期

基金：

美国国家卫生研究院;

关键词：

VENTRAL TEGMENTAL AREA; STRESS; COCAINE; ENHANCEMENT; DEPRESSION; NUCLEUS; NEURONS; PROTEIN;

D O I：

10.1038/nn.3335

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stressors affect dopamine-dependent behaviors such as motivation, although the underlying neurobiological mechanism is not well defined. We report that corticotropin-releasing factor (CRF) acts in the ventral tegmental area (VTA) to reduce the motivation to work for food rewards. CRF in the VTA regulates dopamine output in a stimulus- and pathway-specific manner, offering a mechanism by which acute stress selectively regulates information transmission via the VTA to reprioritize motivated behavior.

引用

页码：383 / U191

页数：4

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