Polycomb complex recruitment in pluripotent stem cells

被引：13

作者：

Barrero, Maria J. ^{[1
]}

Izpisua Belmonte, Juan Carlos ^{[1
,2
]}

机构：

[1] Ctr Regenerat Med Barcelona, E-08003 Barcelona, Spain

[2] Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

来源：

NATURE CELL BIOLOGY | 2013年 / 15卷 / 04期

关键词：

BINDING; DOMAINS;

D O I：

10.1038/ncb2723

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The recruitment of the silencing complex Polycomb group (PcG) to its target sites in mammalian cells has remained elusive. A prevalent model proposes that the PRC1 component is recruited through recognition of methylated H3K27 found at target sites occupied by the PRC2 component. However, mounting evidence suggests that PRC2-independent mechanisms of PRC1 recruitment exist. Three studies describe that the histone demethylase Kdm2b binds to unmethylated CpG islands and recruits a subset of PRC1 complexes to chromatin in pluripotent stem cells.

引用

页码：348 / 350

页数：4

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