Effects of tetrahedral DNA nanostructures on autophagy in chondrocytes

被引：70

作者：

Shi, Sirong ^{[1
]}

Lin, Shiyu ^{[1
]}

Li, Yong ^{[2
]}

Zhang, Tao ^{[1
]}

Shao, Xiaoru ^{[1
]}

Tian, Taoran ^{[1
]}

Zhou, Tengfei ^{[1
]}

Li, Qianshun ^{[1
]}

Lin, Yunfeng ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Sichuan, Peoples R China

[2] Southwest Med Univ, Hosp Stomatol, Dept Oral & Maxillofacial Surg, Luzhou 646000, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 11期

基金：

中国国家自然科学基金;

关键词：

IN-VIVO; SIGNALING PATHWAY; CANCER CELLS; STEM-CELLS; DELIVERY; APOPTOSIS; NANOPARTICLES; INHIBITION; ACTIVATION; THERAPY;

D O I：

10.1039/c7cc09397g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tetrahedral DNA nanostructures (TDNs) have gathered great attention and are being widely used in biomedicine. We demonstrated that autophagy increased after exposure to TDNs (250 nM) along with the up-regulation of several autophagy-related genes and proteins. TDNs enhanced cell autophagy through the PI3K/AKT/mTOR signaling pathway.

引用

页码：1327 / 1330

页数：4

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