Synthesis and antibacterial activity of some substituted 3-(aryl)- and 3-(heteroaryl)indoles

被引：55
作者：
Al-Hiari, YM
Qaisi, AM
El-Abadelah, MM
Voelter, W [1 ]
机构：
[1] Univ Tubingen, Abt Phys Biochem, Inst Physiol Chem, D-72076 Tubingen, Germany
[2] Univ Jordan, Fac Sci, Dept Chem, Amman, Jordan
[3] Univ Jordan, Fac Pharm, Amman, Jordan
来源：
MONATSHEFTE FUR CHEMIE | 2006年 / 137卷 / 02期
关键词：
3-(substituted)phenyl and heteroarylindoles; antibacterial activity;
D O I：
10.1007/s00706-005-0424-6
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A synthesis of 3-(4-methoxycarbonyl-2,6-dinitrophenyl)indole, its 2,6-diamino analog, and 3-(2-amino-4-trifluoromethyl-6-nitrophenyl)indole is described. 4-(Trifluoromethyl)phenyl derivatives exhibit higher antibacterial potency than the former 4-(methoxycarbonyl)phenyl homologs, while 3-(4-trifluoromethyl-2-nitrophenyl)indole was the most active agent in the series, with MIC approximate to 7 mu g/cm(3) against E. coli and S. aureus.
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收藏
页码：243 / 248
页数：6
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