Quality of life in patients with cognitive impairment: validation of the Quality of Life-Alzheimer's Disease scale in Portugal

被引：35

作者：

Barrios, Helena ^{[1
,2
,3
]}

Verdelho, Ana ^{[2
,4
]}

Narciso, Sofia ^{[1
,2
]}

Goncalves-Pereira, Manuel ^{[5
]}

Logsdon, Rebecca ^{[6
]}

de Mendonca, Alexandre ^{[2
,4
]}

机构：

[1] Univ Lisbon, Inst Mol Med, Dementia Grp, P-1699 Lisbon, Portugal

[2] Univ Lisbon, Fac Med, P-1699 Lisbon, Portugal

[3] Hosp Mar, Lisbon, Portugal

[4] Univ Lisbon, Inst Mol Med, Neurosci Lab, P-1699 Lisbon, Portugal

[5] Univ Nova Lisboa, Fac Ciencias Med, CEDOC, P-1200 Lisbon, Portugal

[6] Univ Washington, Sch Nursing, Seattle, WA 98195 USA

来源：

INTERNATIONAL PSYCHOGERIATRICS | 2013年 / 25卷 / 07期

基金：

欧盟地平线“2020”;

关键词：

quality of life; dementia; Alzheimer's disease; mild cognitive impairment; validation; QOL-AD; TASK-FORCE; QOL-AD; DEMENTIA; CAREGIVERS; RATINGS; PEOPLE; ADAPTATION; CRITERIA; VERSION; MODEL;

D O I：

10.1017/S1041610213000379

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background: Quality of Life-Alzheimer's Disease (QOL-AD) is a widely used scale for the study of quality of life in patients with dementia. The aim of this study is the transcultural adaptation and validation of the QOL-AD scale in Portugal. Methods: Translation and transcultural adaptation was performed according to state-of-the-art recommendations. For the validation study, 104 patient/caregiver pairs were enrolled. Patients had mild cognitive impairment or mild-to-moderate dementia (due to Alzheimer's disease or vascular dementia). Participants were recruited in a dementia outpatient clinic setting and a long-term care dementia ward. An additional comparison group of 22 patients without cognitive impairment, and their proxies, was recruited in a family practice outpatient clinic. Sociodemographic information on patients and caregivers was obtained. Acceptability, reliability, and construct validity were analyzed. Results: Internal consistency of the Portuguese version of QOL-AD was good for both patient and caregiver report (Cronbach's alpha = 0.867 and 0.858, respectively). Construct validity was confirmed by the correlation of patient reported QOL-AD with patient geriatric depression scale scores (rho = -0.702, p < 0.001) and satisfaction with life scale scores (rho = 0.543, p < 0.001). Caregiver ratings were correlated with neuropsychiatric inventory (NPI) total score (rho = -0.404, p < 0.001), NPI-distress (rho = -0.346, p < 0.001), and patient Mini-Mental State Examination (rho = 0.319, p < 0.01). QOL-AD patient ratings were higher than caregiver ratings (p < 0.001). Both patient-and caregiver-rated QOL-AD scores were lower in patients with cognitive impairment than in the comparison group without cognitive impairment (p < 0.01). Conclusions: A Portuguese version of QOL-AD with consistent psychometric properties was obtained and is proposed as a useful tool for research and clinical purposes.

引用

页码：1085 / 1096

页数：12

共 42 条

[1]

Aaronson N, 2002, QUAL LIFE RES, V11, P193

[2] What do we know about quality of life in dementia? A review of the emerging evidence on the predictive and explanatory value of disease specific measures of health related quality of life in people with dementia [J].