Shorter telomere length is linked to brain atrophy and white matter hyperintensities

被引：32

作者：

Wikgren, Mikael ^{[1
]}

Karlsson, Thomas ^{[2
]}

Soderlund, Hedvig ^{[3
]}

Nordin, Annelie ^{[1
]}

Roos, Goran ^{[4
]}

Nilsson, Lars-Goran ^{[5
]}

Adolfsson, Rolf ^{[1
]}

Norrback, Karl-Fredrik ^{[1
]}

机构：

[1] Umea Univ, Dept Clin Sci, Div Psychiat, S-90187 Umea, Sweden

[2] Linkoping Univ, Disabil Res Div, Dept Behav Sci & Learning, Linkoping, Sweden

[3] Uppsala Univ, Dept Psychol, Uppsala, Sweden

[4] Umea Univ, Div Pathol, Dept Med Biosci, S-90187 Umea, Sweden

[5] Stockholm Univ, Dept Psychol, S-10691 Stockholm, Sweden

来源：

AGE AND AGEING | 2014年 / 43卷 / 02期

基金：

瑞典研究理事会;

关键词：

brain atrophy; older people; telomere length; white matter hyperintensities; OXIDATIVE STRESS; CEREBRAL ATROPHY; BLOOD-PRESSURE; OLDEST-OLD; MORTALITY; DEMENTIA; DISEASE; COGNITION; LESIONS; MEMORY;

D O I：

10.1093/ageing/aft172

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background: leukocyte telomere length (TL) is considered a marker of biological aging. Several studies have investigated the link between leukocyte TL and aging-associated functional attributes of the brain, but no prior study has investigated whether TL can be linked to brain atrophy and white matter hyperintensities (WMHs); two prominent structural manifestations of brain aging. Methods: we investigated whether leukocyte TL was related to brain atrophy and WMHs in a sample of 102 non-demented individuals aged 64-75 years. Results: shorter TL was related to greater degree of subcortical atrophy (beta = -0.217, P = 0.034), but not to cortical atrophy. Furthermore, TL was 371 bp shorter (P = 0.041) in participants exhibiting subcortical WMHs, and 552 bp shorter (P = 0.009) in older participants exhibiting periventricular WMHs. Conclusion: this study provides the first evidence of leukocyte TL being associated with cerebral subcortical atrophy and WMHs, lending further support to the concept of TL as a marker of biological aging, and in particular that of the aging brain.

引用

页码：212 / 217

页数：7

共 29 条

[1] Differential Associations of Cortical and Subcortical Cerebral Atrophy With Retinal Vascular Signs in Patients With Acute Stroke [J].

Baker, Michelle L. ;

Wang, Jie Jin ;

Liew, Gerald ;

Hand, Peter J. ;

De Silva, Deidre A. ;

Lindley, Richard I. ;

Mitchell, Paul ;

Wong, Meng-Cheong ;

Rochtchina, Elena ;

Wong, Tien Y. ;

Wardlaw, Joanna M. ;

Hankey, Graeme J. .

STROKE, 2010, 41 (10) :2143-2150

[2] A decrease in diastolic blood pressure combined with an increase in systolic blood pressure is associated with a higher cardiovascular mortality in men [J].

Benetos, A ;

Zureik, M ;

Morcet, J ;

Thomas, F ;

Bean, K ;

Safar, M ;

Ducimetière, P ;

Guize, L .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 35 (03) :673-680

[3] Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study [J].

Brouilette, Scott W. ;

Moore, Jasbir S. ;

D McMahon, Alex ;

Thompson, John R. ;

Ford, Ian ;

Shepherd, James ;

Packard, Chris J. ;

Samani, Nilesh J. .

LANCET, 2007, 369 (9556) :107-114

[4] Telomere measurement by quantitative PCR [J].

Cawthon, RM .

NUCLEIC ACIDS RESEARCH, 2002, 30 (10) :e47

[5] Telomeres and telomerase [J].

Chan, SRWL ;

Blackburn, EH .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2004, 359 (1441) :109-121

[6] Pathophysiologic mechanisms in the development of age-related white matter changes of the brain [J].

Fazekas, F ;

Schmidt, R ;

Scheltens, P .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 1998, 9 :2-5

[7] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].

FOLSTEIN, MF ;

FOLSTEIN, SE ;

MCHUGH, PR .

JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198

[8] Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations [J].

Gouw, Alida A. ;

Seewann, Alexandra ;

van der Flier, Wiesje M. ;

Barkhof, Frederik ;

Rozemuller, Annemieke M. ;

Scheltens, Philip ;

Geurts, Jeroen J. G. .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2011, 82 (02) :126-135

[9] Reduced telomere length variation in healthy oldest old [J].

Halaschek-Wiener, Julius ;

Vulto, Irma ;

Fornika, Dan ;

Collins, Jennifer ;

Connors, Joseph M. ;

Le, Nhu D. ;

Lansdorp, Peter M. ;

Brooks-Wilson, Angela .

MECHANISMS OF AGEING AND DEVELOPMENT, 2008, 129 (11) :638-641

[10] Telomere length assessment: Biomarker of chronic oxidative stress? [J].

Houben, Joyce M. J. ;

Moonen, Harald J. J. ;

van Schooten, Frederik J. ;

Hageman, Geja J. .

FREE RADICAL BIOLOGY AND MEDICINE, 2008, 44 (03) :235-246

← 1 2 3 →