Ketogenic diet for infants with epilepsy: A literature review

被引:50
作者
Falsaperla, Raffaele [1 ]
D'Angelo, Gabriella [2 ]
Pratico, Andrea D. [3 ]
Mauceri, Laura [1 ]
Barbagallo, Massimo [1 ]
Pavone, Piero [1 ]
Catanzaro, Stefano [3 ]
Gitto, Eloisa [2 ]
Corsello, Giovanni [4 ]
Ruggieri, Martino [3 ]
机构
[1] Univ Catania, Gen Pediat & Pediat Acute & Emergency Unit, Policlin Vittorio Emanuele Univ Hosp, Catania, Italy
[2] Univ Hosp G Martino, Neonatal & Pediat Intens Care Unit, Dept Human Pathol Adult & Childhood G Barresi, Messina, Italy
[3] Univ Catania, Dept Clin & Expt Med, Unit Rare Dis Nervous Syst Childhood, Sect Pediat & Child Neuropsychiat, Via S Sofia 78, Catania, Italy
[4] Univ Palermo, Dept Maternal & Child Hlth, Palermo, Italy
关键词
Ketogenic diet; Epilepsy; Drug-resistant epilepsy; Glucose transporter type 1 deficiency; Infant; MYOCLONIC-ASTATIC EPILEPSY; GLUT1 DEFICIENCY SYNDROME; MODIFIED ATKINS DIET; BLOOD-BRAIN-BARRIER; REFRACTORY EPILEPSY; GLUCOSE-TRANSPORTER-1; DEFICIENCY; INTRACTABLE EPILEPSY; PEDIATRIC-PATIENTS; GLUCOSE-TRANSPORT; CHILDREN;
D O I
10.1016/j.yebeh.2020.107361
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The ketogenic diet (KD) is an established, nonpharmacological treatment for drug-resistant epilepsy (DRE). Actually, KD and its variants have been shown to be elective and resolute for patients with glucose transporter type 1 (GLUT1) deficiency. The aim of this review was to study the use of KD and its variants in infancy, including the neonatal age, and demonstrate the safety and efficacy of this treatment in patients with the age of 0-23 months affected by DRE already subjected to pharmacological approach attempts. A literature search was conducted using PubMed as the medical database source. We used the age limit of 0-23 months, and we considered only articles published between the years 2015 and 2018, in light of increasing interest worldwide in the use of KD and its variants to manage DRE. We included 52 publications: 1 Cochrane study, 22 retrospective studies, 9 prospective studies, 4 randomized controlled trials ( RCTs), 12 clinical cases, and 4 clinical reviews. Literature data showed that KD and its variants are safe and useful in patients with the age of 0-23 months with DRE. Classical KD is of first choice in the treatment of GUM deficiency. Earlier introduction of KD in GLUT1 promises a better outcome and a decrease in seizure frequency in these patients. (C) 2020 Elsevier Inc. All rights reserved.
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页数:4
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