NMO-IgG positive neuromyelitis optica in a patient with myasthenia gravis but no thymectomy

被引：31

作者：

Kay, Claudia S. K. ^{[1
]}

Scola, Rosana H. ^{[1
]}

Lorenzoni, Paulo J. ^{[1
]}

Jarius, Sven ^{[2
]}

Arruda, Walter O. ^{[1
]}

Werneck, Lineu C. ^{[1
]}

机构：

[1] Univ Fed Parana, Dept Internal Med, Div Neurol, BR-80060000 Curitiba, Parana, Brazil

[2] Univ Heidelberg, Div Mol Neuroimmunol, Dept Neurol, Heidelberg, Germany

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2008年 / 275卷 / 1-2期

关键词：

Neuromyelitis optica; Devic syndrome; Myasthenia gravis; Acetylcholine receptor antibody; NMO-IgG; Aquaporin-4; antibody; Thymectomy;

D O I：

10.1016/j.jns.2008.06.038

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Here we report on a 44-year old woman presenting with both myasthenia gravis (MG) and neuromyelitis optica (NMO). MRI showed transverse myelitis extending from C2 to T4, multifocal demyelinating lesions in the supratentorial white matter, and left optic neuritis. Serological analysis demonstrated antibodies to acetylcholine receptors as well as NMO-IgG. To our knowledge, this is the first case of NMO-IgG positive NMO in a patient with MG but no history of thymectomy or immunosuppression. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：148 / 150

页数：3

共 24 条

[1] Devic disease and thymoma with anti-central nervous system and antithymus antibodies [J].

Antoine, JC ;

Camdessanché, JP ;

Absi, L ;

Lassablière, F ;

Féasson, L .

NEUROLOGY, 2004, 62 (06) :978-980

[2] Neuromyelitis optica - Brain abnormalities in a Brazilian cohort [J].

Bichuetti, Denis Bernardi ;

Rivero, Rene Leandro Magalhaes ;

Oliveira, Daniel May ;

de Souza, Nilton Amorin ;

Abdala, Nitamar ;

Oliveira, Enedina Maria Lobato ;

Gabbai, Alberto Alain .

ARQUIVOS DE NEURO-PSIQUIATRIA, 2008, 66 (01) :1-4

[3] Demyelinating disease in patients with myasthenia gravis [J].

Bichuetti, Denis Bernardi ;

de Barros, Tatiane Martins ;

Oliveira, Enedina Maria Lobato ;

Annes, Marcelo ;

Gabbai, Alberto Alain .

ARQUIVOS DE NEURO-PSIQUIATRIA, 2008, 66 (01) :5-7

[4] Myasthenia gravis: clinical evaluation of 153 patients [J].

Cunha, FMB ;

Scola, RH ;

Werneck, LC .

ARQUIVOS DE NEURO-PSIQUIATRIA, 1999, 57 (2B) :457-464

[5] Recurrent neuromyelitis optica with diffuse central nervous system involvement - Case report [J].

Domingues, RB ;

Kuster, GW ;

Lanes, F ;

Callegaro, D .

ARQUIVOS DE NEURO-PSIQUIATRIA, 2004, 62 (2B) :543-546

[6] Neuromyelitis optica associated with myasthenia gravis: characteristic phenotype in Japanese population [J].

Furukawa, Y. ;

Yoshikawa, H. ;

Yachie, A. ;

Yamada, M. .

EUROPEAN JOURNAL OF NEUROLOGY, 2006, 13 (06) :655-658

[7]

Gotkine M, 2007, NEUROLOGY, V68, P1327

[8] Occurrence of CNS demyelinating disease in patients with myasthenia gravis [J].

Gotkine, Marc ;

Fellig, Yakov ;

Abramsky, Oded .

NEUROLOGY, 2006, 67 (05) :881-883

[9]

Ikeda K, 2007, NEUROLOGY, V68, P1326

[10] Co-occurrence of multiple sclerosis and myasthenia gravis in British Columbia [J].

Isbister, CM ;

Mackenzie, PJ ;

Anderson, D ;

Wade, NK ;

Oger, J .

MULTIPLE SCLEROSIS, 2003, 9 (06) :550-553

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