NMO-IgG positive neuromyelitis optica in a patient with myasthenia gravis but no thymectomy

被引：31
|
作者：
Kay, Claudia S. K. [1 ]
Scola, Rosana H. [1 ]
Lorenzoni, Paulo J. [1 ]
Jarius, Sven [2 ]
Arruda, Walter O. [1 ]
Werneck, Lineu C. [1 ]
机构：
[1] Univ Fed Parana, Dept Internal Med, Div Neurol, BR-80060000 Curitiba, Parana, Brazil
[2] Univ Heidelberg, Div Mol Neuroimmunol, Dept Neurol, Heidelberg, Germany
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2008年 / 275卷 / 1-2期
关键词：
Neuromyelitis optica; Devic syndrome; Myasthenia gravis; Acetylcholine receptor antibody; NMO-IgG; Aquaporin-4; antibody; Thymectomy;
D O I：
10.1016/j.jns.2008.06.038
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Here we report on a 44-year old woman presenting with both myasthenia gravis (MG) and neuromyelitis optica (NMO). MRI showed transverse myelitis extending from C2 to T4, multifocal demyelinating lesions in the supratentorial white matter, and left optic neuritis. Serological analysis demonstrated antibodies to acetylcholine receptors as well as NMO-IgG. To our knowledge, this is the first case of NMO-IgG positive NMO in a patient with MG but no history of thymectomy or immunosuppression. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：148 / 150
页数：3
相关论文
共 50 条
  • [1] NMO-IgG in the diagnosis of neuromyelitis optica
    Jarius, S.
    Franciotta, D.
    Bergamaschi, R.
    Wright, H.
    Littleton, E.
    Palace, J.
    Hohlfeld, R.
    Vincent, A.
    NEUROLOGY, 2007, 68 (13) : 1076 - 1077
  • [2] NMO-IgG: A specific biomarker for neuromyelitis optica
    Weinshenker, Brian G.
    Wingerchuk, Dean M.
    Pittock, Sean J.
    Lucchinetti, Claudia F.
    Lennon, Vanda A.
    DISEASE MARKERS, 2006, 22 (04) : 197 - 206
  • [3] Rituximab for neuromyelitis optica: experience with nine NMO-IgG positive patients
    Brown, A. D.
    Delgado, S.
    Sheremata, W. A.
    MULTIPLE SCLEROSIS, 2007, 13 (09): : 1221 - 1221
  • [4] Neuromyelitis optica and NMO-IgG in European pediatric patients
    Huppke, P.
    Bluethner, M.
    Bauer, O.
    Stark, W.
    Reinhardt, K.
    Huppke, B.
    Gaertner, J.
    NEUROLOGY, 2010, 75 (19) : 1740 - 1744
  • [5] MRI findings of myelitis in NMO-IgG (+) neuromyelitis optica
    Kim, Kwang-Kuk
    MULTIPLE SCLEROSIS, 2009, 15 (01): : 133 - 134
  • [6] NMO-IgG detected in CSF in seronegative neuromyelitis optica
    Klawiter, E. C.
    Alvarez, E., III
    Xu, J.
    Paciorkowski, A. R.
    Md, L. Zhu
    Parks, B. J.
    Cross, A. H.
    Naismith, R. T.
    NEUROLOGY, 2009, 72 (12) : 1101 - 1103
  • [7] Neuromyelitis Optica Spectrum Disorder Following Thymectomy in a Patient with Myasthenia Gravis
    Chey, S. Y.
    Joseph, J. P.
    MULTIPLE SCLEROSIS JOURNAL, 2020, 26 (09) : NP93 - NP94
  • [8] Neuromyelitis optica autoantibody (NMO-IgG) in patients with suspected NMO or limited forms of NMO
    Zuliani, L.
    Blanco, Y.
    Tavolato, B.
    Giometto, B.
    Graus, F.
    Saiz, A.
    MULTIPLE SCLEROSIS, 2006, 12 : S155 - S156
  • [9] NMO-IgG antibodies in neuromyelitis optica:: a report of 2 cases
    Zuliani, L.
    de Munain, A. Lopez
    Martinez, J. Ruiz
    Olascoaga, J.
    Graus, F.
    Saiz, A.
    NEUROLOGIA, 2006, 21 (06): : 314 - 317
  • [10] Neuromyelitis optica: Clinical syndrome and the NMO-IgG autoantibody marker
    Weinshenker, B. G.
    Wingerchuk, D. M.
    ADVANCES IN MULTIPLE SCLEROSIS AND EXPERIMENTAL DEMYELINATING DISEASES, 2008, 318 : 343 - 356
12345