A highly regio- and stereoselective carbocupration of fluoroalkylated internal alkynes: A short total synthesis of the antiestrogenic drug panomifene

被引：72

作者：

Konno, T ^{[1
]}

Daitoh, T ^{[1
]}

Noiri, A ^{[1
]}

Chae, J ^{[1
]}

Ishihara, T ^{[1
]}

Yamanaka, H ^{[1
]}

机构：

[1] Kyoto Inst Technol, Dept Chem & Mat Technol, Sakyo Ku, Kyoto 6068585, Japan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 06期

关键词：

D O I：

10.1021/ol036440n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly regio- and stereoselective carbometalation reaction of fluoroalkylated internal alkynes with organocopper reagents is described. This reaction is utilized successfully in the short, stereoselective total synthesis of the antiestrogenic drug panomifene.

引用

页码：933 / 936

页数：4

共 35 条

[1]

ABRAHAM G, 1979, Patent No. 17853

[2]

ALHASSAN MI, 1987, SYNTHESIS-STUTTGART, P816

[3]

[Anonymous], 1990, DRUGS FUT, V15, P532

[4] Hydrofluorocarbon 245fa: a versatile new synthon in alkyne chemistry [J].