Therapeutic status of hydroxychloroquine in COVID-19: A review

被引：6

作者：

Kaur, Kirandeep ^{[1
]}

Kaushal, Sandeep ^{[1
]}

Kaushal, Ishita Gupta ^{[2
]}

机构：

[1] Dayanand Med Coll & Hosp, Dept Pharmacol, Coll Campus, Ludhiana 141001, Punjab, India

[2] Dayanand Med Coll & Hosp, Dept Emergency Med, Ludhiana, Punjab, India

来源：

JOURNAL OF ANAESTHESIOLOGY CLINICAL PHARMACOLOGY | 2020年 / 36卷

关键词：

COVID-19; hydroxychloroquine; repurposing;

D O I：

10.4103/joacp.JOACP_313_20

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hydroxychloroquine (HCQ), a 4-aminoquinoline, is used worldwide mainly for its role in management of malaria and rheumatoid arthritis. In the present pandemic of coronavirus disease (COVID)-2019, the drug is being repurposed, based on its in vitro evidence of efficacy against coronavirus. There has been a lot of information, for and against the drug, and this review is an effort to bring forth the evidence and current understanding regarding role of HCQ in COVID-19. Clinical studies, case reports, and in vitro studies have generated conflicting results. There are concerns for use of HCQ because of the variable results and the known adverse effects like QT prolongation and hypoglycemia. In the current scenario, recommendations from Indian Council of Medical Research for use of HCQ in the prophylaxis of COVID-19 are being followed.

引用

页码：S160 / S165

页数：6

共 22 条

[1] Finding the Dose for Hydroxychloroquine Prophylaxis for COVID-19: The Desperate Search for Effectiveness [J].

Al-Kofahi, Mahmoud ;

Jacobson, Pamala ;

Boulware, David R. ;

Matas, Arthur ;

Kandaswamy, Raja ;

Jaber, Mutaz M. ;

Rajasingham, Radha ;

Young, Jo-Anne H. ;

Nicol, Melanie R. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2020, 108 (04) :766-769

[2] A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19 [J].

Boulware, David R. ;

Pullen, Matthew F. ;

Bangdiwala, Ananta S. ;

Pastick, Katelyn A. ;

Lofgren, Sarah M. ;

Okafor, Elizabeth C. ;

Skipper, Caleb P. ;

Nascene, Alanna A. ;

Nicol, Melanie R. ;

Abassi, Mahsa ;

Engen, Nicole W. ;

Cheng, Matthew P. ;

LaBar, Derek ;

Lother, Sylvain A. ;

MacKenzie, Lauren J. ;

Drobot, Glen ;

Marten, Nicole ;

Zarychanski, Ryan ;

Kelly, Lauren E. ;

Schwartz, Ilan S. ;

McDonald, Emily G. ;

Rajasingham, Radha ;

Lee, Todd C. ;

Hullsiek, Kathy H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (06) :517-525

[3] Healthcare workers & SARS-CoV-2 infection in India: A case-control investigation in the time of COVID-19 [J].

Chatterjee, Pranab ;

Anand, Tanu ;

Singh, Kh. Jitenkumar ;

Rasaily, Reeta ;

Singh, Ravinder ;

Das, Santasabuj ;

Singh, Harpreet ;

Praharaj, Ira ;

Gangakhedkar, Raman R. ;

Bhargava, Balram ;

Panda, Samiran .

INDIAN JOURNAL OF MEDICAL RESEARCH, 2020, 151 (05) :459-467

[4]

Chen Jun, 2020, Zhejiang Da Xue Xue Bao Yi Xue Ban, V49, P215, DOI 10.3785/j.issn.1008-9292.2020.03.03

[5] SARS-CoV-2 infection in a patient on chronic hydroxychloroquine therapy: Implications for prophylaxis [J].

Dousa, Khalid M. ;

Malavade, Sharad S. ;

Furin, Jennifer ;

Gripshover, Barbara ;

Hatszegi, Marjorie ;

Hojat, Leila ;

Saade, Elie ;

Salata, Robert A. .

IDCASES, 2020, 20

[6] Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies [J].

Gao, Jianjun ;

Tian, Zhenxue ;

Yang, Xu .

BIOSCIENCE TRENDS, 2020, 14 (01) :72-73

[7]

Gautret P, 2020, INT J ANTIMICROB AG, V56, DOI [10.1016/j.ijantimicag.2020.105949, 10.1016/j.ijantimicag.2020.106063]

[8] Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 [J].

Geleris, Joshua ;

Sun, Yifei ;

Platt, Jonathan ;

Zucker, Jason ;

Baldwin, Matthew ;

Hripcsak, George ;

Labella, Angelena ;

Manson, Daniel K. ;

Kubin, Christine ;

Barr, R. Graham ;

Sobieszczyk, Magdalena E. ;

Schluger, Neil W. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (25) :2411-2418

[9] Hydroxychloroquine or Chloroquine for Treatment or Prophylaxis of COVID-19 A Living Systematic Review [J].

Hernandez, Adrian V. ;

Roman, Yuani M. ;

Pasupuleti, Vinay ;

Barboza, Joshuan J. ;

White, C. Michael .

ANNALS OF INTERNAL MEDICINE, 2020, 173 (04) :287-+

[10]

Mehra MR, 2020, LANCET, V395, P1820, DOI [10.1016/S0140-6736(20)31324-6, 10.1016/S0140-6736(20)31180-6]

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