A model of Plasmodium falciparum lactate dehydrogenase and its implications for the design of improved antimalarials and the enhanced detection of parasitaemia

被引：31

作者：

Sessions, RB ^{[1
]}

Dewar, V ^{[1
]}

Clarke, AR ^{[1
]}

Holbrook, JJ ^{[1
]}

机构：

[1] UNIV BRISTOL,SCH MED SCI,DEPT BIOCHEM,BRISTOL BS8 1TD,AVON,ENGLAND

来源：

PROTEIN ENGINEERING | 1997年 / 10卷 / 04期

关键词：

antimalarials; detection of parasitaemia; lactate dehydrogenase structure; malaria;

D O I：

10.1093/protein/10.4.301

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：301 / 306

页数：6

共 23 条

[1]

ALVAREZ JA, 1997, IN PRESS EUR J BIOCH

[2] EXPRESSION OF PLASMODIUM-FALCIPARUM LACTATE-DEHYDROGENASE IN ESCHERICHIA-COLI [J].

BZIK, DJ ;

FOX, BA ;

GONYER, K .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1993, 59 (01) :155-166

[3] INHIBITION OF LACTATE DEHYDROGENASE BY HIGH CONCENTRATIONS OF PYRUVATE - NATURE AND REMOVAL OF INHIBITOR [J].

COULSON, CJ ;

RABIN, BR .

FEBS LETTERS, 1969, 3 (05) :333-&

[4] STRUCTURE AND ENERGETICS OF LIGAND-BINDING TO PROTEINS - ESCHERICHIA-COLI DIHYDROFOLATE REDUCTASE TRIMETHOPRIM, A DRUG-RECEPTOR SYSTEM [J].

DAUBEROSGUTHORPE, P ;

ROBERTS, VA ;

OSGUTHORPE, DJ ;

WOLFF, J ;

GENEST, M ;

HAGLER, AT .

PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1988, 4 (01) :31-47

[5] GOSSYPOL AND DERIVATIVES - A NEW CLASS OF ALDOSE REDUCTASE INHIBITORS [J].

DECK, LM ;

VANDERJAGT, DL ;

ROYER, RE .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (11) :3301-3305

[6] SOURCE OF CATALYSIS IN THE LACTATE-DEHYDROGENASE SYSTEM - GROUND-STATE INTERACTIONS IN THE ENZYME-SUBSTRATE COMPLEX [J].

DENG, H ;

ZHENG, J ;

CLARKE, A ;

HOLBROOK, JJ ;

CALLENDER, R ;

BURGNER, JW .

BIOCHEMISTRY, 1994, 33 (08) :2297-2305

[7] DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE-DEHYDROGENASE FRAMEWORK [J].

DUNN, CR ;

WILKS, HM ;

HALSALL, DJ ;

ATKINSON, T ;

CLARKE, AR ;

MUIRHEAD, H ;

HOLBROOK, JJ .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1991, 332 (1263) :177-&

[8] ENGINEERING SURFACE LOOPS OF PROTEINS - A PREFERRED STRATEGY FOR OBTAINING NEW ENZYME FUNCTION [J].

ELHAWRANI, AS ;

MORETON, KM ;

SESSIONS, RB ;

CLARKE, AR ;

HOLBROOK, JJ .

TRENDS IN BIOTECHNOLOGY, 1994, 12 (05) :207-211

[9]

ESZES C, 1996, PERSPECTIVES PROTEIN

[10] EVIDENCE FOR TERNARY-COMPLEX FORMATION WITH RABBIT-MUSCLE LACTIC ACID DEHYDROGENASE, DIPHOSPHOPYRIDINE NUCLEOTIDE AND PYRUVIC ACID [J].

FROMM, HJ .

BIOCHIMICA ET BIOPHYSICA ACTA, 1961, 52 (01) :199-&

← 1 2 3 →