Wnt/β-catenin pathway in hepatocellular carcinoma pathogenesis and liver physiology

被引：67

作者：

Cavard, Catherine ^{[1
,2
]}

Colnot, Sabine ^{[1
,2
]}

Audard, Virginie ^{[1
,2
,3
]}

Benhamouche, Samira ^{[1
,2
]}

Finzi, Laetitia ^{[1
,2
]}

Torre, Cyril ^{[1
,2
]}

Grimber, Gisele ^{[1
,2
]}

Godard, Cecile ^{[1
,2
]}

Terris, Benoit ^{[1
,2
,3
]}

Perrett, Christine ^{[1
,2
]}

机构：

[1] Univ Paris 05, Inst Cochin, Dept Endocrinol Metab & Canc, CNRS UMR 8104, F-75014 Paris, France

[2] INSERM, U567, F-75014 Paris, France

[3] Hop Cochin, GHU Ouest, Grp Hosp Cochin St Vincent de Paul, Serv Anat & Cytol Pathol,AP HP, F-75014 Paris, France

来源：

FUTURE ONCOLOGY | 2008年 / 4卷 / 05期

关键词：

beta-catenin; hepatocellular carcinoma; liver; metabolic zonation; Wnt pathway;

D O I：

10.2217/14796694.4.5.647

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Wnt/beta-catenin pathway is a key developmental pathway for which alterations have been described in various human cancers. The aberrant activation of this pathway is a major event in human hepatocellular carcinoma, Several laboratories have shown that the Wnt/beta-catenin pathway plays an essential role in all phases of liver development and maturation, and is required for the metabolic function of this organ. In this review, we summarize current knowledge regarding the role of the Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver biology, and the possibilities for developing new therapeutic interventions based on this knowledge.

引用

页码：647 / 660

页数：14

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