β-Lactone Synthetase Found in the Olefin Biosynthesis Pathway

被引：39
作者：
Christenson, James K. [1 ,2 ]
Richman, Jack E. [1 ,2 ]
Jensen, Matthew R. [1 ,2 ]
Neufeld, Jennifer Y. [2 ]
Wilmot, Carrie M. [1 ,2 ]
Wackett, Lawrence P. [1 ,2 ,3 ]
机构：
[1] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Inst Biotechnol, St Paul, MN 55108 USA
[3] Univ Minnesota, Microbial & Plant Genom Inst, St Paul, MN 55108 USA
来源：
BIOCHEMISTRY | 2017年 / 56卷 / 02期
基金：
美国国家卫生研究院;
关键词：
HYDROCARBONS; PROTEASOME; INHIBITOR;
D O I：
10.1021/acs.biochem.6b01199
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The first beta-lactone synthetase enzyme is reported, creating an unexpected link between the biosynthesis of olefinic hydrocarbons and highly functionalized natural products. The enzyme OleC, involved in the microbial biosynthesis of long-chain olefinic hydrocarbons, reacts with syn- and anti-beta-hydroxy acid substrates to yield cis- and trans-beta-lactones, respectively. Protein sequence comparisons reveal that enzymes homologous to OleC are encoded in natural product gene clusters that generate beta-lactone rings, suggesting a common mechanism of biosynthesis.
引用
收藏
页码：348 / 351
页数：4
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