Bacterial epoxide hydrolases of opposite enantiopreference

被引：27

作者：

Krenn, W

Osprian, I

Kroutil, W

Braunegg, G

Faber, K

机构：

[1] Graz Univ, Inst Organ Chem, A-8010 Graz, Austria

[2] Graz Univ Technol, Inst Biotechnol, A-8010 Graz, Austria

来源：

BIOTECHNOLOGY LETTERS | 1999年 / 21卷 / 08期

基金：

奥地利科学基金会;

关键词：

enantiopreference; epoxide hydrolase; methylotrophic bacteria;

D O I：

10.1023/A:1005565108510

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Epoxide hydrolases of matching opposite enantiopreference were found among various Actinomyces spp. While (S)-2,2-disubstituted oxiranes were hydrolyzed by Rhodococcus and Nocardia spp., several strains of methylotrophic bacteria, such as Mycoplana rubra and Methylobacterium spp., exhibited a preference for the (R)-enantiomers. Thus, the stereochemical course of the reaction can be controlled by a simple choice of the appropriate enzyme source.

引用

页码：687 / 690

页数：4

共 15 条

[11] Chemoenzymatic deracemization of (±)-2,2-disubstituted oxiranes [J].