Nanomedicine as a promising approach for diagnosis, treatment and prophylaxis against COVID-19

被引：64
作者：
Abd Ellah, Noura H. [1 ]
Gad, Sheryhan F. [1 ,2 ]
Muhammad, Khalid [3 ]
Batiha, Gaber E. [4 ,5 ]
Hetta, Helal F. [6 ,7 ]
机构：
[1] Assiut Univ, Fac Pharm, Dept Pharmaceut, Assiut 71526, Egypt
[2] Purdue Univ, Dept Ind & Phys Pharm, 575 Stadium Mall Dr, W Lafayette, IN 47907 USA
[3] United Arab Emirates Univ, Coll Sci, Dept Biol, Al Ain, U Arab Emirates
[4] Obihiro Univ Agr & Vet Med, Natl Res Ctr Protozoan Dis, Nishi 2-13,Inada Cho, Obihiro, Hokkaido 0808555, Japan
[5] Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour 22511, Egypt
[6] Assiut Univ, Fac Med, Dept Med Microbiol & Immunol, Assiut 71526, Egypt
[7] Univ Cincinnati, Dept Internal Med, Coll Med, 231 Albert Sabin Way, Cincinnati, OH 45267 USA
来源：
NANOMEDICINE | 2020年 / 15卷 / 21期
关键词：
chloroquine; coronavirus; COVID-19; nanomedicine; remdesivir; SARS-CoV-2; RESPIRATORY SYNDROME CORONAVIRUS; RECEPTOR-BINDING DOMAIN; SARS CORONAVIRUS; SPIKE PROTEIN; GOLD NANOPARTICLES; VIRUS-INFECTION; NEUTRALIZING ANTIBODIES; FUNCTIONAL RECEPTOR; PROTECTIVE IMMUNITY; VACCINES;
D O I：
10.2217/nnm-2020-0247
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The COVID-19 pandemic caused by the newly emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) puts the world in an unprecedented crisis, leaving behind huge human losses and deep socioeconomic damages. Due to the lack of specific treatment against SARS-CoV-2, effective vaccines and antiviral agents are urgently needed to properly restrain the COVID-19 pandemic. Repositioned drugs such as remdesivir have revealed a promising clinical efficacy against COVID-19. Interestingly, nanomedicine as a promising therapeutic approach could effectively help win the battle between coronaviruses (CoVs) and host cells. This review discusses the potential therapeutic approaches, in addition to the contribution of nanomedicine against CoVs in the fields of vaccination, diagnosis and therapy.
引用
收藏
页码：2085 / 2102
页数：18
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