Estrogen synthesis and signaling pathways during aging: from periphery to brain

被引：542

作者：

Cui, Jie ^{[1
]}

Shen, Yong ^{[2
]}

Li, Rena ^{[1
]}

机构：

[1] Roskamp Inst, CHASE, Sarasota, FL 34243 USA

[2] Roskamp Inst, CATSBD, Sarasota, FL 34243 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2013年 / 19卷 / 03期

基金：

美国国家卫生研究院;

关键词：

estrogen synthesis; estrogen metabolism; estrogen receptor signaling; aging; degenerative diseases; LIGAND-INDEPENDENT ACTIVATION; EPIDERMAL-GROWTH-FACTOR; RECEPTOR-ALPHA; GENE-EXPRESSION; ER-ALPHA; AROMATASE EXPRESSION; G-PROTEIN; ALZHEIMERS-DISEASE; GENDER-DIFFERENCES; MULTIPLE PATHWAYS;

D O I：

10.1016/j.molmed.2012.12.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Estrogens are the primary female sex hormones and play important roles in both reproductive and non-reproductive systems. Estrogens can be synthesized in nonreproductive tissues such as liver, heart, muscle, bone and brain, and tissue-specific estrogen synthesis is consistent with a diversity of estrogen actions. In this article we review tissue and cell-specific estrogen synthesis and estrogen receptor signaling in three parts: (i) synthesis and metabolism, (ii) the distribution of estrogen receptors and signaling, and (iii) estrogen functions and related disorders, including cardiovascular diseases, osteoporosis, Alzheimer's disease (AD), and Parkinson disease (PD). This comprehensive review provides new insights into estrogens by giving a better understanding of the tissue-specific estrogen effects and their roles in various diseases.

引用

页码：197 / 209

页数：13

共 128 条

[71] Adipose aromatase gene expression is greater in older women and is unaffected by postmenopausal estrogen therapy [J].