Conservative treatment of early endometrial cancer

被引:26
作者
Bovicelli, Alessandro [1 ,2 ]
D'Andrilli, Giuseppina [1 ]
Giordano, Antonio [1 ,3 ]
De Iaco, Pierandrea [2 ]
机构
[1] Temple Univ, Sbarro Inst Canc Res & Mol Med, Ctr Biotechnol, Coll Sci & Technol, Philadelphia, PA 19122 USA
[2] Univ Bologna, Dept Obstet & Gynecol, Unit Oncol Gynecol, S Orsola Malpighi Hosp, Bologna, Italy
[3] Univ Siena, Dept Human Pathol & Oncol, I-53100 Siena, Italy
关键词
FERTILITY-SPARING TREATMENT; YOUNG-WOMEN; ATYPICAL HYPERPLASIA; ADENOCARCINOMA; PROGESTIN; MANAGEMENT; CARCINOMA;
D O I
10.1002/jcp.24292
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Endometrial cancer is the most common cancer of the female genital tract in Europe and in the United States. Endometrial cancer has increased 21% in incidence since 2008, and the death rate has increased more than 100% over the past two decades. Approximately 15% of patients with endometrial cancer are pre-menopausal. The aim of this review is to discuss the conservative management of endometrial cancer. A number of studies largely support the conservative treatment of endometrial carcinoma (EC) in women desiring future fertility. We focus on the role of progestin hormonal therapy, including the risks associated with non-standard care, appropriate candidate selection, expected outcomes, various progestin agents and recommended follow-up. J. Cell. Physiol. 228: 11541158, 2013. (c) 2012 Wiley Periodicals, Inc.
引用
收藏
页码:1154 / 1158
页数:5
相关论文
共 24 条
[1]   Conservative management of patients with early endometrial carcinoma:: A systematic review [J].
Chiva de Agustin, Luis ;
Lapuente Sastre, Fernando ;
Corraliza Galan, Virginia ;
Granados Galainena, Luis ;
Gonzalez Martin, Antonio ;
Gonzalez Cortijo, Lucia ;
Carballo Gonzalez, Natalia .
CLINICAL & TRANSLATIONAL ONCOLOGY, 2008, 10 (03) :155-162
[2]   A Turkish Gynecologic Oncology Group study of fertility-sparing treatment for early-stage endometrial cancer [J].
Dursun, Polat ;
Erkanli, Serkan ;
Guzel, Ahmet Baris ;
Gultekin, Murat ;
Tarhan, Nefise Cagla ;
Altundag, Ozden ;
Demirkiran, Fuat ;
Bese, Tugan ;
Yildirim, Yusuf ;
Bozdag, Gurkan ;
Yarali, Hakan ;
Simsek, Tayyup ;
Ozcelik, Bulent ;
Ortac, Firat ;
Taskin, Salih ;
Guvenal, Tevfik ;
Ozgul, Nejat ;
Haberal, Ali ;
Vardar, M. Ali ;
Dede, Murat ;
Yenen, Mufit ;
Altintas, Aytekin ;
Arvas, Macit ;
Ayhan, Ali .
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2012, 119 (03) :270-273
[3]  
FARHI DC, 1986, OBSTET GYNECOL, V68, P741
[4]   The fertility-sparing treatment in patients with endometrial atypical hyperplasia and early endometrial cancer: A debated therapeutic option [J].
Gadducci, Angiolo ;
Spirito, Nicoletta ;
Baroni, Elena ;
Tana, Roberta ;
Genazzani, Andrea Riccardo .
GYNECOLOGICAL ENDOCRINOLOGY, 2009, 25 (10) :683-691
[5]   Regression, relapse, and live birth rates with fertility-sparing therapy for endometrial cancer and atypical complex endometrial hyperplasia: a systematic review and metaanalysis [J].
Gallos, Ioannis D. ;
Yap, Jason ;
Rajkhowa, Madhurima ;
Luesley, David M. ;
Coomarasamy, Arri ;
Gupta, Janesh K. .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2012, 207 (04) :266.e1-266.e12
[6]  
GALLUP DG, 1984, OBSTET GYNECOL, V64, P417
[7]   Conservative Treatment With Progestin and Pregnancy Outcomes in Endometrial Cancer [J].
Hahn, Ho-Suap ;
Yoon, Seok-Geun ;
Hong, Jae-Shik ;
Hong, Sung-Ran ;
Park, Sei-Jin ;
Lim, Jae-Yun ;
Kwon, Yong-Soon ;
Lee, In-Ho ;
Lim, Kyung-Taek ;
Lee, Ki-Heon ;
Shim, Jae-Uk ;
Mok, Jung-Eun ;
Kim, Tae-Jin .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2009, 19 (06) :1068-1073
[8]   Conservative management of young patients with endometrial highly-differentiated adenocarcinoma [J].
Kalogiannidis, I. ;
Agorastos, T. .
JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2011, 31 (01) :13-17
[9]   Conservative Treatment With Medroxyprogesterone Acetate Plus Levonorgestrel Intrauterine System for Early-Stage Endometrial Cancer in Young Women Pilot Study [J].
Kim, Mi Kyung ;
Yoon, Bo Sung ;
Park, Hyun ;
Seong, Seok Ju ;
Chung, Hyun Hoon ;
Kim, Jae Weon ;
Kang, Soon Beom .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2011, 21 (04) :673-677
[10]  
Koskas M, 2012, ANTICANCER RES, V32, P1037