Label-free slot-waveguide biosensor for the detection of DNA hybridization

被引：66
作者：
Dar, Tuffail [1 ]
Homola, Jiri [2 ]
Rahman, B. M. Azizur [1 ]
Rajarajan, Muttukrishnan [1 ]
机构：
[1] City Univ London, Sch Engn & Math Sci, London EC1V 0HB, England
[2] Inst Photon & Elect Prague, Dept Opt Sci, Prague 18251, Czech Republic
来源：
APPLIED OPTICS | 2012年 / 51卷 / 34期
关键词：
SURFACE-PLASMON RESONANCE; SILICON-ON-INSULATOR; MICRORING RESONATORS; NANOPARTICLES;
D O I：
10.1364/AO.51.008195
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
A finite element method based on the full-vectorial H-field formulation has been employed to achieve the maximum field penetration in the sensing medium of the slot-waveguide-based ring resonator biosensor. The use of nanometer scale guiding structure where optical mode is confined in a low-index region permits a very compact sensor with high optical intensity in the region, which makes it possible to detect minimum refractive index change, and offers higher sensitivities. We analyze the change in effective refractive index of mode, sensitivity, and power confinement of the proposed slot-waveguide-based ring resonator biosensor for the detection of DNA hybridization. The biosensor exhibited theoretical sensitivity of 856 nm per refractive index unit (RIU) and a detection limit of 1.43 x 10(-6) RIU. (C) 2012 Optical Society of America
引用
收藏
页码：8195 / 8202
页数：8
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