Pathologic Evaluation and Prognostic Implications of Nodal Micrometastases in Breast Cancer

被引：25

作者：

Dutta, Sunil W. ^{[1
]}

Volaric, Ashley ^{[2
]}

Morgan, John T. ^{[1
]}

Chinn, Zachary ^{[2
]}

Atkins, Kristen A. ^{[2
]}

Janowski, Einsley-Marie ^{[1
]}

机构：

[1] Univ Virginia, Dept Radiat Oncol, POB 800383, Charlottesville, VA 22908 USA

[2] Univ Virginia, Dept Pathol, Charlottesville, VA USA

来源：

SEMINARS IN RADIATION ONCOLOGY | 2019年 / 29卷 / 02期

关键词：

SENTINEL LYMPH-NODE; ISOLATED TUMOR-CELLS; AXILLARY DISSECTION; POSTOPERATIVE RADIOTHERAPY; TANGENTIAL FIELDS; WOMEN; IRRADIATION; INVOLVEMENT; RECURRENCE; METASTASES;

D O I：

10.1016/j.semradonc.2018.11.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using modern sentinel lymph node techniques, occult nodal metastases including micro metastases or isolated tumor cells are being increasingly discovered in up to 10% of early stage breast cancers. Furthermore, the rate of nonsentinel lymph node involvement is approximately 10%. However, the impact of these findings on disease-free survival is low, particularly with regards to axillary recurrences. Current evidence suggests small-volume lymph node involvement in breast cancer patients is only one of several factors that should guide adjuvant therapy options. In otherwise favorable patients, adjuvant radiation and systemic therapy can help mitigate the risk of recurrence when omitting axillary lymph node dissection. (C) 2019 The Authors. Published by Elsevier Inc.

引用

页码：102 / 110

页数：9

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