Post-trial administration of vasopressin in humans does not enhance memory formation (vasopressin and memory consolidation)

被引：9

作者：

Gais, S ^{[1
]}

Sommer, M ^{[1
]}

Fischer, S ^{[1
]}

Perras, B ^{[1
]}

Born, J ^{[1
]}

机构：

[1] Univ Lubeck, Lubeck, Germany

来源：

PEPTIDES | 2002年 / 23卷 / 03期

关键词：

vasopressin; memory consolidation; sleep;

D O I：

10.1016/S0196-9781(01)00625-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many animal studies show an enhancing effect of vasopressin (VP) on memory, but not all human studies could confirm this finding. This study examined the influence of post-learning administration of VP (40 IU, intranasally) on the consolidation of declarative memories in healthy humans during different intervals of sleep and waking. We could not find any effect of VP on memory consolidation, but EEG activity indicated a significant arousing influence of VP. Results suggest that if VP affects memory function it might do so primarily at the stage of encoding of the materials to be learned but it leaves unaffected processes of consolidation. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：581 / 583

页数：3

共 22 条

[1] Neuromodulation of memory in the hippocampus by vasopressin [J].