Cystatin C as a potential biomarker for dosing of renally excreted drugs

被引：27
作者：
Brou, Nguessan Aime [3 ,6 ]
Jacqz-Aigrain, Evelyne [3 ,4 ,5 ]
Zhao, Wei [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Shandong Univ, Qianfoshan Hosp, Dept Pharm, Jian, Jiangxi, Peoples R China
[2] Shandong Univ, Sch Pharmaceut Sci, Dept Clin Pharm, Jinan 250012, Peoples R China
[3] Hop Robert Debre, APHP, Dept Paediat Pharmacol & Pharmacogenet, Paris, France
[4] INSERM, Clin Invest Ctr CIC1426, Paris, France
[5] Univ Paris 05, Univ Paris Diderot, EA7323, Paris, France
[6] Univ Felix Houphouet Boigny, Sch Pharmaceut Sci, Dept Clin Pharm & Therapeut, Abidjan, Cote Ivoire
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2015年 / 80卷 / 01期
关键词：
cystatin C; renal function; renal elimination; pharmacokinetics; clearance; glomerular filtration rate; dose regimen; GLOMERULAR-FILTRATION-RATE; POPULATION PHARMACOKINETIC ANALYSIS; SERUM CREATININE; INTENSIVE-CARE; VANCOMYCIN CLEARANCE; KIDNEY-FUNCTION; CLINICAL PHARMACOKINETICS; CYSTIC-FIBROSIS; MARKER; DIGOXIN;
D O I：
10.1111/bcp.12602
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The objective of the present study was to review the available pharmacokinetic evidence for the utility of cystatin C (CysC) as a marker of renal function to predict the dose of renally excreted drugs. The bibliographic search used PubMed and EMBASE databases, from its inception through to January 2014, with the following keywords 'pharmacokinetics' and 'cystatin C'. Sixteen pharmacokinetic publications were identified and seven drugs primarily excreted by the kidney were studied. Among them, only one study was performed in children, the others were performed in adults and/or elderly subjects, either healthy volunteers or patients with variable clinical conditions, such as cystic fibrosis and cancer. Most of studies (n = 13/16) demonstrated that CysC was better correlated with clearance/trough concentration of evaluated drugs compared with creatinine. Our review supports that CysC is a good marker of renal function to predict dose of renally excreted drugs. Efforts should be made to evaluate the impact of CysC in special populations in order to define its clinical value in dosing optimization.
引用
收藏
页码：20 / 27
页数：8
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