What is the role of cannabidiol in refractory epilepsy?

被引:0
作者
LaFleur, Kathryn M. [1 ]
Nemec, Eric C., II [1 ,2 ]
机构
[1] Sacred Heart Univ, PA Program, Fairfield, CT 06825 USA
[2] Sacred Heart Univ, PA Program, Res & Assessment, Fairfield, CT USA
来源
JAAPA-JOURNAL OF THE AMERICAN ACADEMY OF PHYSICIAN ASSISTANTS | 2019年 / 32卷 / 03期
关键词
cannabidiol; cannabis; epilepsy; refractory epilepsy; Dravet syndrome; Lennox-Gastaut syndrome; DRUG-RESISTANT EPILEPSY; SEIZURES; CHILDREN; STATE;
D O I
10.1097/01.JAA.0000553393.36249.df
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The FDA recently approved the first cannabidiol oral medication to treat refractory epilepsy in patients with Dravet syndrome and Lennox- Gastaut syndrome. This article describes the safety and efficacy of cannabidiol treatment in patients with refractory epilepsy.
引用
收藏
页码:16 / 18
页数:3
相关论文
共 19 条
[1]  
American Academy of PAs, PA PRESCR AUTH STAT
[2]  
Anderson CL, 2017, J PEDIATR NEUROL, V15, P143, DOI 10.1055/s-0037-1598109
[3]   Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome [J].
Devinsky, Orrin ;
Patel, Anup D. ;
Cross, J. Helen ;
Villanueva, Vicente ;
Wirrell, Elaine C. ;
Privitera, Michael ;
Greenwood, Sam M. ;
Roberts, Claire ;
Checketts, Daniel ;
VanLandingham, Kevan E. ;
Zuberi, Sameer M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (20) :1888-1897
[4]   Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome [J].
Devinsky, Orrin ;
Cross, J. Helen ;
Laux, Linda ;
Marsh, Eric ;
Miller, Ian ;
Nabbout, Rima ;
Scheffer, Ingrid E. ;
Thiele, Elizabeth A. ;
Wright, Stephen .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (21) :2011-2020
[5]  
Dravet Syndrome Foundation, WHAT IS DRAV SYNDR
[6]   Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy [J].
Geffrey, Alexandra L. ;
Pollack, Sarah F. ;
Bruno, Patricia L. ;
Thiele, Elizabeth A. .
EPILEPSIA, 2015, 56 (08) :1246-1251
[7]   Efficacy of CBD-enriched medical cannabis for treatment of refractory epilepsy in children and adolescents - An observational, longitudinal study [J].
Hausman-Kedem, Moran ;
Menascu, Shay ;
Kramer, Uri .
BRAIN & DEVELOPMENT, 2018, 40 (07) :544-551
[8]   Cannabidiol Treatment for Refractory Seizures in Sturge-Weber Syndrome [J].
Kaplan, Emma H. ;
Offermann, Elizabeth A. ;
Sievers, Jacqueline W. ;
Comi, Anne M. .
PEDIATRIC NEUROLOGY, 2017, 71 :18-23
[9]   Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies [J].
Kwan, Patrick ;
Arzimanoglou, Alexis ;
Berg, Anne T. ;
Brodie, Martin J. ;
Hauser, W. Allen ;
Mathern, Gary ;
Moshe, Solomon L. ;
Perucca, Emilio ;
Wiebe, Samuel ;
French, Jacqueline .
EPILEPSIA, 2010, 51 (06) :1069-1077
[10]   Cannabidiol for treatment of refractory childhood epilepsies: Experience from a single tertiary epilepsy center in Slovenia [J].
Neubauer, David ;
Benedik, Mirjana Perkovic ;
Osredkar, Damjan .
EPILEPSY & BEHAVIOR, 2018, 81 :79-85