Sperm DNA fragmentation: An early and reliable marker of air pollution

被引：44

作者：

Bosco, Liana ^{[1
]}

Notari, Tiziana ^{[2
]}

Ruvolo, Giovanni ^{[3
]}

Roccheri, Maria C. ^{[1
]}

Martino, Chiara ^{[1
]}

Chiappetta, Rosanna ^{[4
]}

Carone, Domenico ^{[4
]}

Lo Bosco, Giosue ^{[5
,9
]}

Carrillo, Laura ^{[3
]}

Raimondo, Salvatore ^{[6
]}

Guglielmino, Antonino ^{[7
]}

Montano, Luigi ^{[8
]}

机构：

[1] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, Viale Sci Ed16, Palermo, Italy

[2] Check Up Polydagnost Ctr, Reprod Med Unit, GEA, Via A De Luca 5, Salerno, Italy

[3] Reprod Biol Ctr, Via Villareale, Palermo, Italy

[4] Reprod Ctr & Androl, Via Scoglio del Tonno, Taranto, Italy

[5] Univ Palermo, Dept Math & Comp Sci, Via Archirafi, Palermo, Italy

[6] Gentile Res Ctr, Seminol Unit, Via Vittorio Veneto 108, Gragnano, NA, Italy

[7] HERA Ctr, Reprod Unit, Catania, Italy

[8] S Francesco dAssisi Hosp, EcoFoodFertil Project Coordinat Unit, Local Hlth Author ASL Salerno, Androl Unit, Via M Clemente, Oliveto Citra, SA, Italy

[9] Euromediterranean Inst Sci & Technol, Via Michele Miraglia, Palermo, Italy

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2018年 / 58卷

关键词：

Apoptosis; SCD; TUNEL; Air pollution; Environmental health; SEMEN QUALITY; REPRODUCTIVE HEALTH; EXPOSURE; MEN; FERTILIZATION; INTEGRITY; DENATURATION; SPERMATOZOA; ENVIRONMENT; INFERTILITY;

D O I：

10.1016/j.etap.2018.02.001

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Environmental factors could have a key role in the continuous and remarkable decline of sperm quality observed in the last decades. This study compared the seminal parameters and sperm DFI in men living in areas with different levels of air pollution. Results demonstrate that both steel plants workers and patients living in a high polluted area show a mean percentage of sperm DNA fragmentation above 30%, highlighting a clear sperm damage. In this work, two different techniques were used to measure sperm DNA damage in patients' groups, finding in both cases a high sperm DFI in patients living in polluted areas. We candidate sperm DNA fragmentation as a valuable early marker of the presence and harmful effects of pollution. We suggest that sperm DNA evaluation could be both an indicator of individual health and reproductive capacity, and a suitable datum to connect the surrounding environment with its effects.

引用

页码：243 / 249

页数：7

共 57 条

[1] Spermatogenesis and mutagenicity of environmental hazards: extrapolation of genetic risk from mouse to man [J].