Prognostic factors and outcome of resected patients with gastrointestinal stromal tumors of small intestine

被引:9
作者
Fan, Rong [1 ]
Zhong, Jie [1 ]
Wang, Zhen-ting [1 ]
Yu, Li-fen [1 ]
Tang, Yong-hua [2 ]
Hu, Wei-guo [3 ]
Zhu, Yan-bo [4 ]
Jin, Xiao-long [4 ]
机构
[1] Shanghai Jiao Tong Univ, Dept Gastroenterol, Sch Med, Shanghai Ruijin Hosp, Shanghai 200025, Peoples R China
[2] Shanghai Jiao Tong Univ, Dept Radiol, Sch Med, Shanghai Ruijin Hosp, Shanghai 200025, Peoples R China
[3] Shanghai Jiao Tong Univ, Dept Gen Surg, Sch Med, Shanghai Ruijin Hosp, Shanghai 200025, Peoples R China
[4] Shanghai Jiao Tong Univ, Dept Pathol, Sch Med, Shanghai Ruijin Hosp, Shanghai 200025, Peoples R China
关键词
Gastrointestinal stromal tumors; Small intestine; Prognostic factors; MANAGEMENT; SARCOMAS; JEJUNUM; ILEUM;
D O I
10.1007/s12032-010-9688-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We document the clinical behavior of gastrointestinal stromal tumors (GISTs) of the small intestine and identify predictors for long-term disease-free survival (DFS) for small intestine GIST patients. From December 2001 to 2008, 114 consecutive patients with mesenchymal tumors involving the small intestine were enrolled. There were 54 male and 60 female (50.6%) patients. After a median follow-up period of 36 months (ranging from 12 to 96 months), recurrence was noted in 19 patients (16.7%) with a median time of 20 months (ranging from 7 to 50 months). There were 12 patients (10.5%) who died of GISTs with a median time from recurrence to death of 14 months (ranging from 8 to 22 months). Univariate analysis by log-rank test indicated that tumor size and mitotic activity were statistically significant for DFS (P = 0.001 and 0.036, respectively). Tumor size was the only significant predictive factor for DFS according to multivariate analysis (P = 0.006). Small tumor size, indicating low risk, predicted more favorable DFS of small intestine GIST patients who underwent curative resection.
引用
收藏
页码:S185 / S188
页数:4
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