Development of Multi Scale Structured Al/Al2O3 Nanowires for Controlled Cell Guidance

被引：16

作者：

Lee, Juseok ^{[1
]}

Miro, Marina M. ^{[1
]}

Akkan, Cagri K. ^{[1
]}

Haidar, Ayman ^{[2
]}

Metzger, Wolfgang ^{[3
]}

Schwarz, Lukas K. ^{[4
]}

Zaporojtchenko, Vladimir ^{[5
]}

Schaefer, Karl H. ^{[4
]}

Abdul-Khaliq, Hashim ^{[2
]}

Veith, Michael ^{[1
,6
]}

Aktas, Cenk ^{[1
]}

机构：

[1] Leibniz Inst New Mat, D-66123 Saarbrucken, Germany

[2] Univ Saarland, Clin Pediat Cardiol, D-66421 Homburg, Germany

[3] Univ Saarland, Dept Trauma Hand & Reconstruct Surg, D-66421 Homburg, Germany

[4] Univ Appl Sci Kaiserslautern, D-66482 Zweibrucken, Germany

[5] Univ Kiel, Fac Engn, Chair Multicomponent Mat, D-24143 Kiel, Germany

[6] Univ Saarland, Inst Inorgan Chem, D-66041 Saarbrucken, Germany

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2013年 / 9卷 / 02期

关键词：

Alumina; Bi-Phasic Nanowire; Chemical Vapor Deposition; Laser Interference Lithography; Cell Guidance; SURFACES; ALUMINA;

D O I：

10.1166/jbn.2013.1522

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Cell responses to surface and contact cell guidance are of great interest in bio-applications especially on nano- and micro scale features. Recently we showed selective cell responses on Al/Al2O3 bi-phasic nanowires (NWs). In this context, Al/Al2O3 NWs were synthesized by the chemical vapor deposition of ((BuOAlH2)-Bu-t)(2). Afterwards, linear periodic nano- and micro structured NWs were formed using laser interference lithography (LIL) technique to study the contact guidance of neurons from rat dorsal root ganglion (DRG), human umbilical vein smooth muscle cells (HUVSMC), human umbilical vein endothelial cells (HUVEC) and human osteoblast (HOB). LIL treatment did not alter surface chemistry of NWs. From our preliminary research LIL patterned NWs lead to alignment of axons contrary to non-patterned NWs. Morphology of HUVSMC changed from poly- to linear shapes and strong alignment was observed while HUVEC and HOB were not affected.

引用

页码：295 / 298

页数：4

共 12 条

[1] Improved Endothelialisation on Nanostructured Surfaces
Aktas, Cenk
Haidar, Ayman
Miro, Marina Martinez
Doerrschuck, Eva
Lee, Juseok
Veith, Michael
Abdul-Khaliq, Hashim
[J]. ADVANCES IN INNOVATIVE MATERIALS AND APPLICATIONS, 2011, 324 : 105 - +
[2] The surface modification of polymers to modulate endothelial cell growth
Colligon, JS
Dekker, A
Curry, A
Kirkpatrick, CJ
[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1996, 7 (02) : 119 - 123
[3] Hennessy T.C., 2011, Lithography: Principles, Processes and Materials. Engineering tools
[4] Nanomaterials for Neural Interfaces
Kotov, Nicholas A.
Winter, Jessica O.
Clements, Isaac P.
Jan, Edward
Timko, Brian P.
Campidelli, Stephane
Pathak, Smita
Mazzatenta, Andrea
Lieber, Charles M.
Prato, Maurizio
Bellamkonda, Ravi V.
Silva, Gabriel A.
Kam, Nadine Wong Shi
Patolsky, Fernando
Ballerini, Laura
[J]. ADVANCED MATERIALS, 2009, 21 (40) : 3970 - 4004
[5] Schimmelpfennig L, 2011, TISSUE ENG PT A, V17, P568
[6] Chemical vapour deposition of aluminium based micro- and nanostructured surfaces for biological applications
Veith, M.
Petersen, C.
Aktas, O. C.
Metzger, W.
Oberringer, M.
Pohlemann, T.
Mueller, M.
Gerbes, S.
[J]. MATERIALS LETTERS, 2008, 62 (23) : 3842 - 3845
[7] Veith M, 2010, CERAM TRANS, V214, P117
[8] Adhesion of fibroblasts on micro- and nanostructured surfaces prepared by chemical vapor deposition and pulsed laser treatment
Veith, M.
Aktas, O. C.
Metzger, W.
Sossong, D.
Wazir, H. Ullah
Grobelsek, I.
Puetz, N.
Wennemuth, G.
Pohlemann, T.
Oberringer, M.
[J]. BIOFABRICATION, 2010, 2 (03)
[9] Precursorchemistry with metalalkoxides and their use for nano-scaled materials
Veith, Michael
[J]. ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS, 2008, 222 (2-3): : 287 - 305
[10] Design and evaluation of nanophase alumina for orthopaedic/dental applications
Webster, TJ
Siegel, RW
Bizios, R
[J]. NANOSTRUCTURED MATERIALS, 1999, 12 (5-8): : 983 - 986

← 1 2 →