Synthesis and hypoglycemic activity of some new theophylline derivatives

被引：10

作者：

Alafeefy, Ahmed M. ^{[1
]}

Alqasoumi, Saleh I. ^{[2
]}

Hamid, Sami G. Abdel ^{[1
,3
]}

El-Tahir, Kamal E. H. ^{[4
]}

Mohamed, Menshawy ^{[1
,3
]}

Zain, Mohamed E. ^{[5
]}

Awaad, Amani S. ^{[6
]}

机构：

[1] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia

[2] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh, Saudi Arabia

[3] Al Azhar Univ, Dept Organ Chem, Fac Pharm, Cairo, Egypt

[4] King Saud Univ, Coll Pharm, Dept Pharmacol & Toxicol, Riyadh, Saudi Arabia

[5] King Saud Univ, Dept Bot & Microbiol, Fac Sci, Riyadh, Saudi Arabia

[6] King Saud Univ, Dept Chem, Fac Sci, Riyadh, Saudi Arabia

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2014年 / 29卷 / 03期

关键词：

Hypoglycemic; isoindoline; synthesis; theophylline; HEPATIC GLUCOSE-PRODUCTION; ADENOSINE-RECEPTOR; STIMULATION; ANTAGONISTS;

D O I：

10.3109/14756366.2013.795957

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thirty-one new theophylline derivatives have been synthesized and evaluated for their hypoglycemic activity. Compounds 24 (56% reduction) and 31 (57% reduction) showed better hypoglycemic activity than the standard drug glibenclamide which showed 52% reduction in serum glucose level. Compound 27 remarkably reduced serum glucose level by 53%. Ten compounds showed varying degrees of hypoglycemic activity ranging from 20 to 37% reduction in serum glucose level compared to the standard drug. The aromatic amide functionality is the common feature of these theophylline hypoglycemic derivatives. However, anthranilamide and or aliphatic amides proved to be the least active compounds in the present series.

引用

页码：443 / 448

页数：6

共 22 条

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