Advanced cell therapies: targeting, tracking and actuation of cells with magnetic particles

被引：68

作者：

Connell, John J. ^{[1
]}

Patrick, P. Stephen ^{[1
]}

Yu, Yichao ^{[1
]}

Lythgoe, Mark F. ^{[1
]}

Kalber, Tammy L. ^{[1
]}

机构：

[1] UCL, UCL Ctr Adv Biomed Imaging, Div Med, London WC1E 6DD, England

来源：

REGENERATIVE MEDICINE | 2015年 / 10卷 / 06期

基金：

英国工程与自然科学研究理事会; 英国医学研究理事会; 英国国家替代、减少和改良动物研究中心;

关键词：

cell tracking; magnetic actuation; magnetic targeting; MRI; regenerative medicine; SPION; MESENCHYMAL STEM-CELLS; IRON-OXIDE NANOPARTICLES; ENDOTHELIAL PROGENITOR CELLS; MARROW STROMAL CELLS; MR CONTRAST AGENTS; IN-VITRO MODEL; GENE-THERAPY; RESONANCE TRACKING; EXTRACELLULAR-MATRIX; DELIVERY-SYSTEM;

D O I：

10.2217/rme.15.36

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Regenerative medicine would greatly benefit from a new platform technology that enabled measurable, controllable and targeting of stem cells to a site of disease or injury in the body. Superparamagnetic iron-oxide nanoparticles offer attractive possibilities in biomedicine and can be incorporated into cells, affording a safe and reliable means of tagging. This review describes three current and emerging methods to enhance regenerative medicine using magnetic particles to guide therapeutic cells to a target organ; track the cells using MRI and assess their spatial localization with high precision and influence the behavior of the cell using magnetic actuation. This approach is complementary to the systemic injection of cell therapies, thus expanding the horizon of stem cell therapeutics.

引用

页码：757 / 772

页数：16

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