Development of a Standard Reference Material for Metabolomics Research

被引：94

作者：

Phinney, Karen W. ^{[1
]}

Ballihaut, Guillaume ^{[2
]}

Bedner, Mary ^{[2
]}

Benford, Brandi S. ^{[2
]}

Camara, Johanna E. ^{[2
]}

Christopher, Steven J. ^{[2
]}

Davis, W. Clay ^{[2
]}

Dodder, Nathan G. ^{[2
]}

Eppe, Gauthier ^{[2
]}

Lang, Brian E. ^{[3
]}

Long, Stephen E. ^{[2
]}

Lowenthal, Mark S. ^{[1
]}

McGaw, Elizabeth A. ^{[2
]}

Murphy, Karen E. ^{[2
]}

Nelson, Bryant C. ^{[3
]}

Prendergast, Jocelyn L. ^{[2
]}

Reiner, Jessica L. ^{[2
]}

Rimmer, Catherine A. ^{[2
]}

Sander, Lane C. ^{[2
]}

Schantz, Michele M. ^{[2
]}

Sharpless, Katherine E. ^{[2
]}

Sniegoski, Lorna T. ^{[2
]}

Tai, Susan S. -C. ^{[2
]}

Thomas, Jeanice B. ^{[2
]}

Vetter, Thomas W. ^{[2
]}

Welch, Michael J. ^{[2
]}

Wise, Stephen A. ^{[2
]}

Wood, Laura J. ^{[2
]}

Guthrie, William F. ^{[4
]}

Hagwood, Charles R. ^{[4
]}

Leigh, Stefan D. ^{[4
]}

Yen, James H. ^{[4
]}

Zhang, Nien-Fan ^{[4
]}

Chaudhary-Webb, Madhu ^{[5
]}

Chen, Huiping ^{[5
]}

Fazili, Zia ^{[5
]}

LaVoie, Donna J. ^{[5
]}

McCoy, Leslie F. ^{[5
]}

Momin, Shahzad S. ^{[5
]}

Paladugula, Neelima ^{[5
]}

Pendergrast, Elizabeth C. ^{[5
]}

Pfeiffer, Christine M. ^{[5
]}

Powers, Carissa D. ^{[5
]}

Rabinowitz, Daniel ^{[5
]}

Rybak, Michael E. ^{[5
]}

Schleicher, Rosemary L. ^{[5
]}

Toombs, Bridgette M. H. ^{[5
]}

Xu, Mary ^{[5
]}

Zhang, Mindy ^{[5
]}

Castle, Arthur L. ^{[6
]}

机构：

[1] NIST, Biomol Measurement Div, Gaithersburg, MD 20899 USA

[2] NIST, Div Chem Sci, Gaithersburg, MD 20899 USA

[3] NIST, Biosyst & Biomat Div, Gaithersburg, MD 20899 USA

[4] NIST, Stat Engn Div, Gaithersburg, MD 20899 USA

[5] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA

[6] NIDDK, NIH, Bethesda, MD 20892 USA

来源：

ANALYTICAL CHEMISTRY | 2013年 / 85卷 / 24期

关键词：

MASS-SPECTROMETRY; HUMAN PLASMA; ACID-METABOLISM; HUMAN URINE; HPLC-MS; METABONOMICS; DISEASE; PERFORMANCE; DIAGNOSIS; RISK;

D O I：

10.1021/ac402689t

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NTH), has developed a Standard Reference Material (SRM) to support technology development in metabolomics research. SRM 1950 Metabolites in Human Plasma is intended to have metabolite concentrations that are representative of those found in adult human plasma. The plasma used in the preparation of SRM 1950 was collected from both male and female donors, and donor ethnicity targets were selected based upon the ethnic makeup of the U.S. population. Metabolomics research is diverse in terms of both instrumentation and scientific goals. This SRM was designed to apply broadly to the field, not toward specific applications. Therefore, concentrations of approximately 100 analytes, including amino acids, fatty acids, trace elements, vitamins, hormones, selenoproteins, clinical markers, and perfluorinated compounds (PFCs), were determined. Value assignment measurements were performed by NIST and the Centers for Disease Control and Prevention (CDC). SRM 1950 is the first reference material developed specifically for metabolomics research.

引用

页码：11732 / 11738

页数：7

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