The effect of a muscarinic receptor 1 gene variant on grey matter volume in schizophrenia

被引：13
作者：
Cropley, Vanessa L. [1 ,2 ,3 ]
Scarr, Elizabeth [3 ,4 ]
Fornito, Alex [1 ,2 ,5 ]
Klauser, Paul [1 ,2 ,5 ]
Bousman, Chad A. [1 ,2 ,3 ,6 ]
Scott, Rodney [7 ,8 ,9 ]
Cairns, Murray J. [7 ,8 ,9 ]
Tooney, Paul A. [7 ,8 ,9 ]
Pantelis, Christos [1 ,2 ,3 ,6 ]
Dean, Brian [3 ,4 ]
机构：
[1] Univ Melbourne, Melbourne Neuropsychiat Ctr, Dept Psychiat, Carlton, Vic 3053, Australia
[2] Melbourne Hlth, Carlton, Vic 3053, Australia
[3] Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia
[4] Florey Inst Neurosci & Mental Hlth, Mol Psychiat Lab, Parkville, Vic 3052, Australia
[5] Monash Univ, Inst Cognit & Clin Neurosci, Brain & Mental Hlth Lab, Clayton, Vic 3168, Australia
[6] Florey Inst Neurosci & Mental Hlth, Parkville, Vic 3052, Australia
[7] Univ Newcastle, Sch Biomed Sci & Pharm, Callaghan, NSW 3208, Australia
[8] Univ Newcastle, Prior Res Ctr Translat Neurosci & Mental Hlth, Callaghan, NSW 3208, Australia
[9] Hunter Med Res Inst, Neurobehav Genet Unit, New Lambton, NSW 2305, Australia
来源：
PSYCHIATRY RESEARCH-NEUROIMAGING | 2015年 / 234卷 / 02期
基金：
英国医学研究理事会; 澳大利亚国家健康与医学研究理事会; 澳大利亚研究理事会; 瑞士国家科学基金会;
关键词：
Schizophrenia; Schizoaffective disorder; Muscarinic M1 receptor (CHRM1); Single nucleotide polymorphism; Voxel-based morphometry; Imaging; Set-shifting; INTERINDIVIDUAL DIFFERENCES; NEUROCOGNITIVE DEFICITS; PREMOTOR CORTEX; COGNITION; MOTOR; ASSOCIATION; SYMPTOMS; DISEASE; AREAS;
D O I：
10.1016/j.pscychresns.2015.09.004
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Previous research has demonstrated that individuals with schizophrenia who are homozygous at the c.267C > A single nucleotide polymorphism (rs2067477) within the cholinergic muscarinic M1 receptor (CHRM1) perform less well on the Wisconsin Card Sorting Test (WCST) than those who are heterozygous. This study sought to determine whether variation in the rs2067477 genotype was associated with differential changes in brain structure. Data from 227 patients with established schizophrenia or schizoaffective disorder were obtained from the Australian Schizophrenia Research Bank. Whole-brain voxel-based morphometry was performed to compare regional grey matter volume (GMV) between the 267C/C (N = 191) and 267C/A (N=36) groups. Secondary analyses tested for an effect of genotype on cognition (the WCST was not available). Individuals who were homozygous (267C/C) demonstrated significantly reduced GMV in the right precentral gyrus compared to those who were heterozygous (267C/A). These preliminary results suggest that the rs2067477 genotype is associated with brain structure in the right precentral gyrus in individuals with schizophrenia/schizoaffective disorder. Future studies are required to replicate these results and directly link the volumetric reductions with specific cognitive processes. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：182 / 187
页数：6
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