Dopamine and cognitive functioning in de novo subjects with Parkinson's disease: Effects of pramipexole and pergolide on working memory

被引:67
作者
Costa, Alberto [1 ]
Peppe, Antonella [1 ]
Dell'Agnello, Grazia [2 ]
Caltagirone, Carlo [1 ,3 ]
Carlesimo, Giovanni Augusto [1 ,3 ]
机构
[1] Fdn IRCCS S Lucia, I-00179 Rome, Italy
[2] Univ Pisa, Dipartimento Neurosci, I-56100 Pisa, Italy
[3] Univ Roma Tor Vergata, I-00173 Rome, Italy
关键词
Parkinson's disease; Working memory; Dopamine; Cognitive functions; BECK DEPRESSION INVENTORY; LATERAL FRONTAL-CORTEX; PREFRONTAL CORTEX; BASAL GANGLIA; MODULATION; DEFICITS; RECEPTOR; PERFORMANCE; AGONIST; MODEL;
D O I
10.1016/j.neuropsychologia.2009.01.039
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Very few studies have investigated the relationship between dopaminergic therapy and working memory (WM) functioning in Parkinson's disease (PD) patients. The aim of the present study was to explore the effects of pharmacological treatment with pergolide (a D-1 + D-2 receptor agonist) and pramipexole (a D-2 + D-3 receptor agonist) on performance in visual-spatial, visual-object, and verbal WM tasks in PD patients. Participants included 19 "de novo" PD patients and 13 healthy controls (HC). The experimental task consisted of an n-back paradigm with verbal, visual-object, or visual-spatial stimuli. PD patients performed the task twice: after 18-24 h of therapy wash-out and after administration of pergolide (nine patients) or pramipexole (ten patients). HCs performed the task only once, without drug administration. Depending on how they performed in the "Off' and "On" therapy conditions, the nine PD patients each were classified into groups of low performers (i.e., performance on the n-back paradigm was below the median value of the experimental sample) and high performers (i.e., performance was above the median value). One PD patient was excluded from the analysis because his performance pattern clearly revealed that he was an outlier. In the low performer PD patients, administration of both pergolide and pramipexole improved accuracy on all WM tasks. No effect of the drugs was found in the high performer patients. The results of the present study show that stimulation of dopaminergic receptors improves high-level WM processes in PD patients, possibly by modulating activity in frontal-striatal circuits. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1374 / 1381
页数:8
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