Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain

被引：75

作者：

Campbell, Claudia M. ^{[2
]}

Edwards, Robert R. ^{[2
,3
]}

Carmona, Cheryl ^{[1
]}

Uhart, Magdalena ^{[4
]}

Wand, Gary ^{[4
]}

Carteret, Alene ^{[1
]}

Kim, Yu Kyeong ^{[5
]}

Frost, James ^{[6
]}

Campbell, James N. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21287 USA

[3] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, Chestnut Hill, MA 02467 USA

[4] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21287 USA

[5] Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Nucl Med, Songnam 463707, South Korea

[6] Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21287 USA

来源：

PAIN | 2009年 / 141卷 / 1-2期

关键词：

GTP cyclohydrolase; GCH1; Genetics; Pain; Experimental pain; Capsaicin; INDIVIDUAL-DIFFERENCES; ETHNIC-DIFFERENCES; SENSITIVITY; RESPONSES; MODULATION; HAPLOTYPE; STIMULI;

D O I：

10.1016/j.pain.2008.10.023

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Though it is clear that genomic variability plays an integral role in accounting for pain sensitivity, controversy exists over which genes are involved. While recent data suggest a "protective" (i.e., less pain) haplotype in the GTP cyclohydrolase (GCH1) gene, other research has failed to confirm this association. Possibly, the effects of single nucleotide polymorphisms (SNPs) vary depending on the pain task. The current investigation analyzed the association of five previously identified GCH1 SNPs with ratings of pain induced by topical high concentration (10%) capsaicin applied to the skin of 39 healthy human volunteers. Each of the GCH1 polymorphisms was associated with lower pain ratings. When combined, three of the five accounted for a surprisingly high 35% of the inter-individual variance in pain ratings. We conclude that SNPs of the GCH1 gene may profoundly affect the ratings of pain induced by capsaicin. (C) 2008 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

引用

页码：114 / 118

页数：5

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