Switchable cascade C-H annulation to polycyclic pyryliums and pyridiniums: discovering mitochondria-targeting fluorescent probes

被引:20
作者
Chen, Xingyu [1 ]
Yan, Lipeng [1 ]
Liu, Yanhong [1 ]
Yang, Yudong [1 ]
You, Jingsong [1 ]
机构
[1] Sichuan Univ, Key Lab Green Chem & Technol, Minist Educ, Coll Chem, 29 Wangjiang Rd, Chengdu 610064, Peoples R China
关键词
ONE-POT ACCESS; CATALYZED ANNULATION; ALKYNES; ACTIVATION; CLEAVAGE;
D O I
10.1039/d0cc06997c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Disclosed herein is a counterion additive-switched rhodium-catalyzed cascade triple C-H annulation of 4-hydroxy-1-naphthaldehydes with alkynes, in which six chemical bonds are formed in one-pot. This reaction enables the rapid assembly of diverse polycyclic pyrylium and pyridinium fluorophores, which leads to two specific mitochondria-labeling reagents with low cytotoxicity and superior photostability.
引用
收藏
页码:15080 / 15083
页数:4
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