Novel Approach to Estimate Kidney and Cyst Volumes Using Mid-Slice Magnetic Resonance Images in Polycystic Kidney Disease

被引：46

作者：

Bae, Kyongtae T. ^{[1
]}

Tao, Cheng ^{[1
]}

Wang, Jinhong ^{[1
]}

Kaya, Diana ^{[1
]}

Wu, Zhiyuan ^{[1
]}

Bae, Junu T. ^{[1
]}

Chapman, Arlene B. ^{[3
]}

Torres, Vicente E. ^{[4
]}

Grantham, Jared J. ^{[5
]}

Mrug, Michal ^{[6
]}

Bennett, William M. ^{[7
]}

Flessner, Michael F. ^{[8
]}

Landsittel, Doug P. ^{[2
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Radiol, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Sch Med, Dept Internal Med, Pittsburgh, PA 15213 USA

[3] Emory Univ, Sch Med, Dept Internal Med, Atlanta, GA USA

[4] Mayo Coll Med, Dept Internal Med, Rochester, MN USA

[5] Univ Kansas, Med Ctr, Dept Internal Med, Kansas City, KS 66103 USA

[6] Univ Alabama Birmingham, Div Nephrol, Birmingham, AL USA

[7] Legacy Good Samaritan Hosp, Portland, OR USA

[8] Natl Inst Diabet & Digest & Kidney Dis, NIH, Bethesda, MD USA

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 2013年 / 38卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Kidney; Polycystic kidney disease; Kidney volume; Renal cysts; Magnetic resonance imaging; CONSORTIUM; PROGRESSION; COHORT; CRISP; ADPKD; MRI;

D O I：

10.1159/000355375

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To evaluate whether kidney and cyst volumes can be accurately estimated based on limited area measurements from magnetic resonance (MR) images of patients with autosomal dominant polycystic kidney disease (ADPKD). Materials and Methods: MR coronal images of 178 ADPKD participants from the Consortium for Radiologic Imaging Studies of ADPKD (CRISP) were analyzed. For each MR image slice, we measured kidney and renal cyst areas using stereology and region-based thresholding methods, respectively. The kidney and cyst 'observed' volumes were calculated by summing up the area measurements of all the slices covering the kidney. To estimate the volume, we selected a coronal mid-slice in each kidney and multiplied its area by the total number of slices ('PANK2' for kidney and 'PANC2' for cyst). We then compared the kidney and cyst volumes predicted from PANK2 and PANC2, respectively, to the corresponding observed volumes, using a linear regression analysis. Results: The kidney volume predicted from PANK2 correlated extremely well with the observed kidney volume (R-2 = 0.994 for the right kidney and 0.991 for the left kidney). The linear regression coefficient multiplier to PANK2 that best fit the kidney volume was 0.637 (95% CI: 0.629-0.644) for the right kidney and 0.624 (95% CI: 0.616-0.633) for the left kidney. The correlation between the cyst volume predicted from PANC2 and the observed cyst volume was also very high (R-2 = 0.984 for the right kidney and 0.967 for the left kidney). The least squares linear regression coefficient for PANC2 was 0.637 (95% CI: 0.624-0.649) for the right kidney and 0.608 (95% CI: 0.591-0.625) for the left kidney. Conclusion: Kidney and cyst volumes can be closely approximated by multiplying the product of the mid-slice area measurement and the total number of slices in the coronal MR images of ADPKD kidneys by 0.61-0.64. This information will help save processing time needed to estimate total kidney and cyst volumes of ADPKD kidneys. (C) 2013 S. Karger AG, Basel

引用

页码：333 / 341

页数：9

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