Moyamoya Disease Susceptibility Variant RNF213 p.R4810K Increases the Risk of Ischemic Stroke Attributable to Large-Artery Atherosclerosis

被引：86

作者：

Okazaki, Shuhei ^{[1
,6
]}

Morimoto, Takaaki ^{[1
,7
]}

Kamatani, Yoichiro ^{[8
,10
]}

Kamimura, Teppei ^{[1
]}

Kobayashi, Hatasu ^{[7
,11
]}

Harada, Kouji ^{[7
]}

Tomita, Tsutomu ^{[2
]}

Higashiyama, Aya ^{[2
]}

Takahashi, Jun C. ^{[3
]}

Nakagawara, Jyoji ^{[3
]}

Koga, Masatoshi ^{[4
]}

Toyoda, Kazunori ^{[4
]}

Washida, Kazuo ^{[1
]}

Saito, Satoshi ^{[1
]}

Takahashi, Atsushi ^{[5
,8
]}

Hirata, Makoto ^{[12
]}

Matsuda, Koichi ^{[13
]}

Mochizuki, Hideki ^{[6
]}

Chong, Michael ^{[14
]}

Pare, Guillaume ^{[14
]}

O'Donnell, Martin ^{[15
,16
]}

Ago, Tetsuro ^{[17
]}

Hata, Jun ^{[18
]}

Ninomiya, Toshiharu ^{[18
]}

Dichgans, Martin ^{[19
,20
]}

Debette, Stephanie ^{[21
]}

Kubo, Michiaki ^{[9
]}

Koizumi, Akio ^{[7
]}

Ihara, Masafumi ^{[1
]}

机构：

[1] Natl Cerebral & Cardiovasc Ctr, Dept Neurol, 5-7-1 Fujishiro Dai, Suita, Osaka 5658565, Japan

[2] Natl Cerebral & Cardiovasc Ctr, NCVC Biobank, Osaka, Japan

[3] Natl Cerebral & Cardiovasc Ctr, Dept Neurosurg, Osaka, Japan

[4] Natl Cerebral & Cardiovasc Ctr, Dept Cerebrovasc Med, Osaka, Japan

[5] Natl Cerebral & Cardiovasc Ctr, Dept Genom Med, Res Inst, Osaka, Japan

[6] Osaka Univ, Grad Sch Med, Dept Neurol, Suita, Osaka, Japan

[7] Kyoto Univ, Grad Sch Med, Dept Hlth & Environm Sci, Kyoto, Japan

[8] RIKEN, Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan

[9] RIKEN, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan

[10] Kyoto Univ, Grad Sch Med, Ctr Genom Med, Kyoto, Japan

[11] Chubu Univ, Coll Life & Hlth Sci, Dept Biomed Sci, Kasugai, Aichi, Japan

[12] Univ Tokyo, Inst Med Sci, Tokyo, Japan

[13] Univ Tokyo, Grad Sch Frontier Sci, Chiba, Japan

[14] McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada

[15] Natl Univ Ireland Galway, Hlth Res Board Clin Res Facil, Galway, Ireland

[16] Univ Hosp Galway, Galway, Ireland

[17] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Fukuoka, Japan

[18] Kyushu Univ, Grad Sch Med Sci, Dept Epidemiol & Publ Hlth, Fukuoka, Fukuoka, Japan

[19] Ludwig Maximilians Univ Munchen, Med Ctr, Inst Stroke & Dementia Res, Munich, Germany

[20] Munich Cluster Syst Neurol SyNergy, Munich, Germany

[21] Bordeaux Univ Hosp, Inst Neurodegenerat Dis, Dept Neurol, Bordeaux, France

来源：

CIRCULATION | 2019年 / 139卷 / 02期

关键词：

atherosclerosis; constriction; pathologic; genetic predisposition to disease; moyamoya disease; RING finger domains; stroke;

D O I：

10.1161/CIRCULATIONAHA.118.038439

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：295 / 298

页数：4

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