Ring-expansion reaction for the synthesis of 2-(trifluoromethyl)oxazoles and 3-(trifluoromethyl)-1,2,4-triazines

被引：6

作者：

Teng, Yun ^{[1
,2
]}

Fang, Tingyu ^{[1
,2
]}

Lin, Zitong ^{[3
]}

Qin, Lu ^{[3
]}

Jiang, Mengfan ^{[3
]}

Wu, Wei ^{[3
]}

You, Yi ^{[1
,2
]}

Weng, Zhiqiang ^{[1
,2
,3
]}

机构：

[1] Fuzhou Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Peoples R China

[2] Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Electrochem Energy Storage Mat, Fuzhou 350108, Peoples R China

[3] Minjiang Univ, Coll Mat & Chem Engn, Fujian Engn Res Ctr New Chinese Lacquer Mat, Fuzhou 350108, Peoples R China

来源：

TETRAHEDRON LETTERS | 2022年 / 107卷

关键词：

Trifluoroacetic anhydride; Trifluoromethyl; 1; 2; 4-Triazine; Oxazole; Ring-expansion reaction; OXAZOLE; CYCLIZATION; CHEMISTRY; TRIFLUOROMETHYLATION; DERIVATIVES; THIAZOLE; ACCESS; ACID;

D O I：

10.1016/j.tetlet.2022.154100

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A ring-expansion reaction of 2H-azirine with trifluoroacetic anhydride for the synthesis of 2-(trifluo-romethyl)oxazoles is disclosed. The reaction features readily available reactants, relatively mild condi-tions, and high yields of products. The generated 2-(trifluoromethyl)oxazole core could be easily converted into 3-(trifluoromethyl)-1,2,4-triazines through hydrazinolysis reaction.(c) 2022 Elsevier Ltd. All rights reserved.

引用

页数：6

共 48 条

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