Genetics and molecular biology of intramedullary spinal cord tumors

被引：10
作者：
Chi, JH [1 ]
Cachola, K [1 ]
Parsa, AT [1 ]
机构：
[1] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA
来源：
NEUROSURGERY CLINICS OF NORTH AMERICA | 2006年 / 17卷 / 01期
关键词：
D O I：
10.1016/j.nec.2005.10.002
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Certain genetic syndromes are associated with intramedullary spinal cord tumors and provide a special opportunity to study their genetics and molecular biology. Historically, ependymoma and astrocytoma of the spinal cord have been little distinguished from their cerebral counterparts. More and more evidence suggests that distinct differences in genetics and molecular biology exist between primary tumors in the brain and spinal cord with similar histology, however.
引用
收藏
页码：1 / +
页数：6
相关论文
共 33 条
  • [1] Localization of a putative low-penetrance ependymoma susceptibility locus to 22q 11 using a chromosome 22 tiling-path genomic microarray
    Arnmerlaan, ACJ
    de Bustos, C
    Ararou, A
    Buckley, PG
    Mantripragada, KK
    Verstegen, MJ
    Hulsebos, TJM
    Dumanski, JP
    [J]. GENES CHROMOSOMES & CANCER, 2005, 43 (04) : 329 - 338
  • [2] Loss of heterozygosity reveals non-VHL allelic loss in hemangioblastomas at 22q13
    Beckner, ME
    Sasatomi, E
    Swalsky, PA
    Hamilton, RL
    Pollack, IF
    Finkelstein, SD
    [J]. HUMAN PATHOLOGY, 2004, 35 (09) : 1105 - 1111
  • [3] MOLECULAR ANALYSIS OF GENETIC CHANGES IN EPENDYMOMAS
    BIJLSMA, EK
    VOESTEN, AMJ
    BIJLEVELD, EH
    TROOST, D
    WESTERVELD, A
    MEREL, P
    THOMAS, G
    HULSEBOS, TJM
    [J]. GENES CHROMOSOMES & CANCER, 1995, 13 (04) : 272 - 277
  • [4] Birch BD, 1996, NEUROSURGERY, V39, P135, DOI 10.1097/00006123-199607000-00026
  • [5] Spinal tumors in neurofibromatosis Type 2. Is emerging knowledge of genotype predictive of natural history?
    Dow, G
    Biggs, N
    Evans, G
    Gillespie, J
    Ramsden, R
    King, A
    [J]. JOURNAL OF NEUROSURGERY-SPINE, 2005, 2 (05) : 574 - 579
  • [6] Molecular genetic analysis of ependymal tumors - NF2 mutations and chromosome 22q loss occur preferentially in intramedullary spinal ependymomas
    Ebert, C
    von Haken, M
    Meyer-Puttlitz, B
    Wiestler, OD
    Reifenberger, G
    Pietsch, T
    von Deimling, A
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (02) : 627 - 632
  • [7] Inverse correlation between genetic aberrations and malignancy grade in ependymal tumors: a paradox?
    Gilhuis, HJ
    van der Laak, J
    Wesseling, P
    Boerman, RH
    Beute, G
    Teepen, JLMJ
    Grotenhuis, JA
    Kappelle, AC
    [J]. JOURNAL OF NEURO-ONCOLOGY, 2004, 66 (1-2) : 111 - 116
  • [8] The impact of molecular genetic analysis of the VHL gene in patients with haemangioblastomas of the central nervous system
    Gläsker, S
    Bender, BU
    Apel, TW
    Natt, E
    van Velthoven, V
    Scheremet, R
    Zentner, J
    Neumann, HPH
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1999, 67 (06) : 758 - 762
  • [9] Central nervous system manifestations in VHL:: genetics, pathology and clinical phenotypic features
    Gläsker, S
    [J]. FAMILIAL CANCER, 2005, 4 (01) : 37 - 42
  • [10] Reconsideration of biallelic inactivation of the VHL tumour suppressor gene in hemangioblastomas of the central nervous system
    Gläsker, S
    Bender, BU
    Apel, TW
    van Velthoven, V
    Mulligan, LM
    Zentner, J
    Neumann, NPH
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2001, 70 (05) : 644 - 648
1234