Copper(I)-only catalyzed reactions of (E)-2,3-difluoro-3-stannylacrylic ester with acid chlorides and mechanistic studies of the "copper effect" in Stille coupling reactions

被引：43

作者：

Wang, Y ^{[1
]}

Burton, DJ ^{[1
]}

机构：

[1] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 06期

关键词：

D O I：

10.1021/ol053023x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reactions of (E)-2,3-difluoro-3-stannylacrylic ester with acid chlorides under catalysis of CuI stereospecifically afforded ethyl (2Z)-2,3-difluoro-4-oxo-substituted 2-butenoates in good yields. Moreover, direct spectroscopic observation of the corresponding organocopper reagent was observed for the first time in Stille coupling reactions of organostannanes.

引用

页码：1109 / 1111

页数：3

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