A comparative study of microwave assisted and conventional synthesis of 2,3-dihydro-2-aryl-4-[4-(2-oxo-2H-chromen-3-yl)-1,3-thiazol-2-ylamino]-1,5-benzothiazepines and its antimicrobial activity

被引：16

作者：

Raval, Jignesh P. ^{[1
]}

Desai, Jignasu T. ^{[2
]}

Desai, Chintan K. ^{[2
]}

Desai, Kishor R. ^{[2
]}

机构：

[1] Ashok & Rita Patel Inst Integrated Res Biotechnol, Vallabh Vidyanagar 388120, Gujarat, India

[2] Veer Narmad S Gujarat Univ, Dept Chem, Surat 395007, India

来源：

ARKIVOC | 2008年

关键词：

N-substituted cinnamamides; N-[4-(2-oxo-2H-chromen-3-yl)-1,3-thiazol-2-yl] acetamide; 1,5-benzothiazipines; microwave irradiation (MWI); IR; NMR (H-1 & C-13); mass spectral analysis; antibacterial and antifungal activities;

D O I：

10.3998/ark.5550190.0009.c25

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of 2,3-dihydro-2-aryl-4-[4-(2-oxo-2H-chromen-3-yl)-1,3-thiazol-2-ylamino]- 1,5-benzothiazipine 6a-j were synthesized from N-[4-(2-oxo-2H-chromen-3-yl)-1,3-thiazol-2- yl]-cinnamamide derivatives 4a-j. The structures of these compounds were confirmed by IR, NMR (H-1 & C-13) & mass spectral analysis. A considerable increase in the reaction rate has been observed with better yield using microwave irradiation in comparison to conventional thermal treatment. The newly synthesized compounds were evaluated for antimicrobial activity against variety of bacterial strains and some of these compounds have shown significant antibacterial and antifungal activities.

引用

页码：233 / 244

页数：12

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