Age-specific vaccine effectiveness of seasonal 2010/2011 and pandemic influenza A(H1N1) 2009 vaccines in preventing influenza in the United Kingdom

被引：33

作者：

Pebody, R. G. ^{[1
]}

Andrews, N. ^{[1
]}

Fleming, D. M. ^{[2
]}

McMenamin, J. ^{[3
]}

Cottrell, S. ^{[4
]}

Smyth, B. ^{[5
]}

Durnall, H. ^{[2
]}

Robertson, C. ^{[3
,6
,9
]}

Carman, W. ^{[7
]}

Ellis, J. ^{[8
]}

Sebastian-Pillai, P. ^{[8
]}

Zambon, M. ^{[8
]}

Kearns, C. ^{[5
]}

Moore, C. ^{[4
]}

Thomas, D. Rh. ^{[4
]}

Watson, J. M. ^{[1
]}

机构：

[1] Hlth Protect Agcy, Hlth Protect Serv Colindale, London NW9 5EQ, England

[2] Royal Coll Gen Practitioners, Res & Surveillance Ctr, Birmingham, W Midlands, England

[3] Hlth Protect Scotland, Glasgow, Lanark, Scotland

[4] Publ Hlth Wales, Cardiff, S Glam, Wales

[5] Publ Hlth Agcy No Ireland, Belfast, Antrim, North Ireland

[6] Univ Strathclyde, Glasgow, Lanark, Scotland

[7] West Scotland Specialist Virol Ctr, Glasgow, Lanark, Scotland

[8] Hlth Protect Agcy, Microbiol Serv Colindale, London NW9 5EQ, England

[9] Int Prevent Res Inst, Lyon, France

来源：

EPIDEMIOLOGY AND INFECTION | 2013年 / 141卷 / 03期

关键词：

Influenza; influenza vaccines; vaccine-preventable diseases; LABORATORY-CONFIRMED INFLUENZA; CHILDREN; 6;

D O I：

10.1017/S0950268812001148

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

An analysis was undertaken to measure age-specific vaccine effectiveness (VE) of 2010/11 trivalent seasonal influenza vaccine (TIV) and monovalent 2009 pandemic influenza vaccine (PIV) administered in 2009/2010. The test-negative case-control study design was employed based on patients consulting primary care. Overall TIV effectiveness, adjusted for age and month, against confirmed influenza A(H1N1)pdm 2009 infection was 56% (95% CI 42-66); age-specific adjusted VE was 87% (95% CI 45-97) in <5-year-olds and 84% (95% CI 27-97) in 5- to 14-year-olds. Adjusted VE for PIV was only 28% (95% CI -6 to 51) overall and 72% (95% CI 15-91) in <5-year-olds. For confirmed influenza B infection, TIV effectiveness was 57% (95% CI 42-68) and in 5- to 14-year-olds 75% (95% CI 32-91). TIV provided moderate protection against the main circulating strains in 2010/2011, with higher protection in children. PIV administered during the previous season provided residual protection after 1 year, particularly in the <5 years age group.

引用

页码：620 / 630

页数：11

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