Quantitative Assessment of Interim PET/CT Could Have More Prognostic Relevance than Visual Assessment for Predicting Clinical Outcome of Extranodal Diffuse Large B Cell Lymphoma

被引：4
作者：
Baek, Dong Won [1 ]
Cho, Hee Jeong [1 ]
Kim, Ju-Hyung [1 ]
Sohn, Sang Kyun [1 ]
Song, Ga-Young [2 ]
Ahn, Seo-Yeon [2 ]
Jung, Sung-Hoon [2 ]
Ahn, Jae Sook [2 ]
Lee, Je-Jung [2 ]
Kim, Hyeoung-Joon [2 ]
Jeong, Shin-Young [3 ]
Hong, Chae Moon [3 ]
Min, Jung-Joon [4 ]
Moon, Joon-Ho [1 ]
Yang, Deok-Hwan [2 ]
机构：
[1] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Hematol Oncol, Sch Med, 130 Dongdeok Ro, Daegu 41944, South Korea
[2] Chonnam Natl Univ, Hwasun Hosp, Sch Med, Dept Hematol Oncol, Hwasun, South Korea
[3] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Nucl Med, Daegu, South Korea
[4] Chonnam Natl Univ, Hwasun Hosp, Sch Med, Dept Nucl Med, Hwasun, South Korea
来源：
IN VIVO | 2020年 / 34卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
DLBCL; extranodal; interim PET/CT; SUV; Deauville 5-point scale; POSITRON-EMISSION-TOMOGRAPHY; NON-HODGKINS-LYMPHOMA; SUV-BASED ASSESSMENT; EARLY F-18-FDG PET; FDG-PET; INTERNATIONAL WORKSHOP; RESPONSE ASSESSMENT; ELDERLY-PATIENTS; R-CHOP; CRITERIA;
D O I：
10.21873/invivo.12018
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background/Aim: The present study retrospectively investigated the predictive accuracy of interim positron emission tomography/computed tomography (iPET/CT) based on the Deauville 5-point scale (5-PS) and a quantitative SUV-based assessment in patients with extranodal (EN) diffuse large B cell lymphoma (DLBCL). Patients and Methods: The Deauville 5-PS and the SUVmax reduction (Delta SUVmax) assessment for interpreting the response to iPET/CT were used. Results: A total of 163 patients were enrolled in this study. With a median follow- up of 52.5 months, Delta SUVmax successfully predicted the survival outcomes of patients with one extranodal (EN) involvement in terms of overall survival (OS) (p=0.012) and progression-free survival (PFS) (p<0.001). Visual assessment using the Deauville 5-PS did not predict survival outcomes in patients with one or more EN involvements in terms of OS and PFS. Conclusion: The quantitative SUV-based assessment with iPET/CT was a significant prognosticator for long-term survival outcomes, especially in patients with one EN involvement.
引用
收藏
页码：2127 / 2134
页数：8
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