Lack of association of A-6G polymorphism of AGT gene with essential hypertension in the Chinese population

被引:5
作者
Li, Yan-yan [1 ]
机构
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Geriatr, Nanjing 210029, Jiangsu, Peoples R China
关键词
A-6G polymorphism; AGT gene; angiotensinogen; hypertension; meta-analysis; ELEVATION MYOCARDIAL-INFARCTION; HUMAN ANGIOTENSINOGEN GENE; ACUTE CORONARY SYNDROMES; BLOOD-PRESSURE; NERVOUS-SYSTEM; CHEST-PAIN; METAANALYSIS; DISEASE; ANGINA; WOMEN;
D O I
10.2459/JCM.0b013e328355a726
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background The angiotensinogen (AGT) A-6G gene polymorphism has been indicated to be related to the susceptibility of essential hypertension. However, the results are still unclear. Objective and methods To survey the relationship between AGT A-6G gene polymorphism and essential hypertension, 18 separate studies with 9306 patients were analyzed through meta-analysis. The random-effect model was used to calculate the pooled odds ratio (OR) and its corresponding 95% confidence interval (CI). Results In this AGT A-6G gene polymorphism and essential hypertension meta-analysis of the Chinese population, the distribution of the G-allele frequency was 0.23 for the essential hypertension group and 0.21 for the control group. The association between the AGT A-6G gene polymorphism and essential hypertension in the entire sample population was not significant. The pooled OR for the frequency of the G allele was 1.10 (95% CI 0.96 to 1.27, P-heterogeneity < 0.00001, P = 0.17). In the stratified analysis by ethnicity, a significant association in Li and Mongolian ethnicities (P <= 0.05) was achieved. However, no significant association was found in other ethnicities such as Han, Tibetan, Kazakh, Bai and Yi (P > 0.05). Conclusions The current meta-analysis suggested that AGT A-6G gene polymorphism might not be related to the increased risk of essential hypertension in the entire Chinese population. However, the G-allele of AGT A-6G might predispose to essential hypertension in the Li and Mongolian ethnicities.
引用
收藏
页码:505 / 510
页数:6
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